(R)-(+)-N-苄基-1-苯乙胺合成路线 （共 41 条）
反应条件
5 palladium on charcoal; hydrogen in water T=20 - 25°C; P=3345.86 Torr; 0.5 h; Large scale;
参考文献
Huckabee, Brian K.; Lin, Sechoing; Smith, Traci L.; Stuk, Timothy L.
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 594 - 595
反应条件
1: With benzylamine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (+)-6-dicyclohexylphosphanyl-2'-diphenylphosphanyl-2-methoxy-1,1'-biphenyl in methanol T=20°C; 1 h; 2: With hydrogen in methanol T=30°C; P=37503.8 Torr; 15 h; Product distribution / selectivity;
参考文献
LONZA AG
Patent: WO2006/2731 A1, 2006 ;
Location in patent: Page/Page column 19-20 ;
反应条件
n-butyllithium in toluene
参考文献
BASF Aktiengesellschaft
Patent: US5919961 A1, 1999 ;
反应条件
1: ethanol / 3 h / Heating 2: 184 g / NaBH4 / 72 h / 20 °C View Scheme
参考文献
Blackburn, Leonie; Taylor, Richard J. K.
Organic Letters, 2001 , vol. 3, # 11 p. 1637 - 1639
反应条件
N,N'-dimethyl-N,N'-propyleneurea; sodium carbonate T=100°C; 1.5 h;
参考文献
Juaristi; Murer; Seebach
Synthesis, 1993 , # 12 p. 1243 - 1246
反应条件
1: molecular sieves 4 Angstroem / toluene / Heating 2: H2; [Ir(1,5-cyclooctadiene)Cl]2; (R)-tert-butylphosphinoylbenzene / pyridine / toluene / 120 h / 0 °C / 18751.5 Torr View Scheme
参考文献
Jiang, Xiao-Bin; Minnaard, Adriaan J.; Hessen, Bart; Feringa, Ben L.; Duchateau, Alexander L. L.; Andrien, Jean G. O.; Boogers, Jeroen A. F.; De Vries, Johannes G.
Organic Letters, 2003 , vol. 5, # 9 p. 1503 - 1506
反应条件
1: molecular sieves 4 Angstroem / toluene / Heating 2: H2; [Ir(1,5-cyclooctadiene)Cl]2; (R)-tert-butylphosphinoylbenzene / pyridine / toluene / 120 h / 0 °C / 18751.5 Torr View Scheme
参考文献
Pyne, Stephen G.; Bloem, Peter; Griffith, Renate
Tetrahedron, 1989 , vol. 45, # 22 p. 7013 - 7022
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Franchi, Paola; Lucarini, Marco; Mezzina, Elisabetta; Pedulli, Gian Franco
Journal of the American Chemical Society, 2004 , vol. 126, # 13 p. 4343 - 4354
反应条件
1: Et3N / CH2Cl2 / 0.5 h 2: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Franchi, Paola; Lucarini, Marco; Mezzina, Elisabetta; Pedulli, Gian Franco
Journal of the American Chemical Society, 2004 , vol. 126, # 13 p. 4343 - 4354
反应条件
3,3'-bis(9-anthryl)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate; diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate in toluene T=57°C; P=125.263 Torr; 120 h; Inert atmosphereDean-Stark trap; optical yield given as percent eeenantioselective reaction;
参考文献
Gautier, Franois-Moana; Jones, Simon; Li, Xianfu; Martin, Stephen J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 22 p. 7860 - 7868
