2-氨基-3-氯-5-溴吡啶合成路线 （共 5 条）
反应条件
1: With N-chloro-succinimide in N,N-dimethyl-formamide T=0 - 20°C; 2: With sodium hydroxide in water; N,N-dimethyl-formamide pH=7 - 8;
参考文献
WO2010/83246 A1, ;
Page/Page column 143-144 ;
反应条件
bromine; sodium carbonate in acetic acid T=20°C; 0.5 h;
参考文献
WO2013/29548 A1, ;
Page/Page column 87; 88 ;
反应条件
in N,N-dimethyl-formamide Cooling with ice;
参考文献
EP2221301 A1, ;
Page/Page column 45-46 ;
反应条件
pyridine; hydrogen fluoride; sodium nitrite T=20°C; Cooling with ice;
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: EP2221301 A1, 2010 ;
Location in patent: Page/Page column 46 ;
反应条件
potassium hydroxide in tetrahydrofuran; diethylene glycol dimethyl ether; cyclohexane; ethylene glycol; ethyl acetate
参考文献
Ciba-Geigy Corporation
Patent: US4033975 A1, 1977 ;
