1-(1,3-丁二炔-1-基)-3-甲基苯合成路线 （共 11 条）
反应条件
methanol; potassium carbonate in dichloromethane
T=20°C; 1 h;
参考文献
Xue, Ya-Xin; Zhu, Yuan-Yuan; Gao, Long-Mei; He, Xiao-Yue; Liu, Na; Zhang, Wu-Yi; Yin, Jun; Ding, Yunsheng; Zhou, Hongping; Wu, Zong-Quan
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4706 - 4713
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / -45 °C / Inert atmosphere
1.2: -45 - -10 °C / Inert atmosphere
1.3: -45 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetone / 0.33 h / Inert atmosphere
View Scheme
参考文献
Deperasinska; Szemik-Hojniak; Osowska; Rode; Szczepanik; Wisniewski, L.; Lis; Szafert
Journal of Photochemistry and Photobiology A: Chemistry, 2011 , vol. 217, # 2-3 p. 299 - 307
反应条件
manganese(IV) oxide; potassium hydroxide in diethyl ether
Ambient temperature;
参考文献
Godt, Adelheid
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7471 - 7474
反应条件
1: Pd(PPh3)2Cl2, CuI, piperidine / tetrahydrofuran / 0 - 20 °C
2: MnO2, KOH / diethyl ether
3: 47 percent / hydroxylamine hydrochloride, CuCl, aq. EtNH2 / methanol / 4 h / Ambient temperature
4: MnO2, KOH / diethyl ether / Ambient temperature
View Scheme
参考文献
Godt, Adelheid
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7471 - 7474
反应条件
1: MnO2, KOH / diethyl ether
2: 47 percent / hydroxylamine hydrochloride, CuCl, aq. EtNH2 / methanol / 4 h / Ambient temperature
3: MnO2, KOH / diethyl ether / Ambient temperature
View Scheme
参考文献
Godt, Adelheid
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7471 - 7474
反应条件
1: 1.) aq. NaOH, 2.) SOCl2 / 2) ether, reflux, 6 h
2: 91 percent / Et3N / toluene / 3 h / Ambient temperature
3: 33 percent Spectr. / 1 h / 750 °C / 0 - 0.1 Torr
View Scheme
参考文献
Aitken, R. Alan; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2461 - 2466
反应条件
1: 91 percent / Et3N / toluene / 3 h / Ambient temperature
2: 33 percent Spectr. / 1 h / 750 °C / 0 - 0.1 Torr
View Scheme
参考文献
Aitken, R. Alan; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2461 - 2466
反应条件
1: NaOH, benzyltriethylammonium chloride / H2O; diethyl ether / 120 h
2: 1.) aq. NaOH, 2.) SOCl2 / 2) ether, reflux, 6 h
3: 91 percent / Et3N / toluene / 3 h / Ambient temperature
4: 33 percent Spectr. / 1 h / 750 °C / 0 - 0.1 Torr
View Scheme
参考文献
Aitken, R. Alan; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2461 - 2466
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 6 h / 55 °C / |Inert atmosphere
2: potassium carbonate; methanol / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Xue, Ya-Xin; Zhu, Yuan-Yuan; Gao, Long-Mei; He, Xiao-Yue; Liu, Na; Zhang, Wu-Yi; Yin, Jun; Ding, Yunsheng; Zhou, Hongping; Wu, Zong-Quan
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4706 - 4713
反应条件
T=750°C; P=0.001 - 0.1 Torr; 1 h;
参考文献
Aitken, R. Alan; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2461 - 2466
