manganese(IV) oxide in tetrahydrofuran T=45°C; 18 h;

tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; water; toluene Suzuki coupling; Inert atmosphereReflux;

di-tert-butyl dicarbonate; hydrogen; palladium diacetate; triphenylphosphine in tetrahydrofuran T=100°C; P=67506.8 - 82508.3 Torr; 24 h; Product distribution / selectivity;

hydrogen; trimethylacetic anhydride; palladium diacetate; triphenylphosphine in tetrahydrofuran T=100°C; P=75007.5 Torr; 20 h; Product distribution / selectivity;

1: With lithium aluminium tetrahydride; ethyl acetate in tetrahydrofuran T=0°C; 2: 5-(4-fluorophenyl)pyridine-3-carboxylic acid piperidine amide in tetrahydrofuran T=-7°C; 3 h; 3: With sodium hydroxide; sulfuric acid; water Product distribution / selectivity; more than 3 stages;

1: bromine; acetic acid / 2.5 h / Reflux 2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / Inert atmosphere; Reflux View Scheme