6-氯-2-(甲基硫代)-5-硝基嘧啶-4-胺合成路线 （共 5 条）
反应条件
ammonia; triethylamine in tetrahydrofuran; isopropyl alcohol
T=20°C; Cooling;
参考文献
JANSSEN RandD IRELAND; BONFANTI, Jean-François; DOUBLET, Frédéric Marc Maurice; EMBRECHTS, Werner; FORTIN, Jérôme Michel Claude; MC GOWAN, David Craig; MULLER, Philippe; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2013/68438 A1, 2013 ;
Location in patent: Page/Page column 30 ;
反应条件
ammonia; triethylamine in tetrahydrofuran
T=-20 - 0°C; 1.5 h;
参考文献
Gilead Sciences, Inc.
Patent: US2010/143301 A1, 2010 ;
Location in patent: Page/Page column 46 ;
反应条件
1: trifluoroacetic acid; nitric acid / 5 - 45 °C
2: N,N-dimethyl-aniline; trichlorophosphate / 0 - 100 °C
3: ammonia; triethylamine / tetrahydrofuran; isopropyl alcohol / 20 °C / |Cooling
View Scheme
参考文献
JANSSEN RandD IRELAND; BONFANTI, Jean-François; DOUBLET, Frédéric Marc Maurice; EMBRECHTS, Werner; FORTIN, Jérôme Michel Claude; MC GOWAN, David Craig; MULLER, Philippe; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2013/68438 A1, 2013 ;
反应条件
1: N,N-dimethyl-aniline; trichlorophosphate / 0 - 100 °C
2: ammonia; triethylamine / tetrahydrofuran; isopropyl alcohol / 20 °C / |Cooling
View Scheme
参考文献
JANSSEN RandD IRELAND; BONFANTI, Jean-François; DOUBLET, Frédéric Marc Maurice; EMBRECHTS, Werner; FORTIN, Jérôme Michel Claude; MC GOWAN, David Craig; MULLER, Philippe; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2013/68438 A1, 2013 ;
反应条件
N,N-diethylaniline; trichlorophosphate
2 h; Heating;
参考文献
Harnden, Michael R.; Hurst, Derek T.
Australian Journal of Chemistry, 1990 , vol. 43, # 1 p. 47 - 53
