2-(2-氨基苯甲酰)吡啶合成路线 （共 17 条）
反应条件
1: N-(2-pyridinyl)-2,2-dimethylpropanamide With n-butyllithium in hexane T=-78 - 0°C; 4 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=0 - 20°C; 3: With hydrogenchloride in methanol; water T=100°C; 16 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/9967 A2, 2005 ;
Location in patent: Page/Page column 28 ;
WO 2005/009967 A2
反应条件
ammonia in water Heating;
参考文献
Guengoer, Timur; Marsais, Francis; Queguiner, Guy
Journal of Organometallic Chemistry, 1981 , vol. 215, # 2 p. 139 - 150
反应条件
ammonium hydroxide T=100°C; 2 h;
参考文献
Trecourt, Francois; Marsais, Francis; Guengoer, Timur; Queguiner, Guy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 9 p. 2409 - 2415
反应条件
hydrogenchloride T=90°C; 24 h;
参考文献
Estel; Linard; Marsais; Godard; Queguiner
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 1 p. 105 - 112
反应条件
ammonium acetate in acetic acid 8 h; Heating;
参考文献
Sollhuber-Kretzer; Troschutz
Archiv der Pharmazie, 1982 , vol. 315, # 9 p. 783 - 790
反应条件
ammonium acetate in acetic acid 8 h; Heating;
参考文献
Sollhuber-Kretzer; Troschutz
Archiv der Pharmazie, 1982 , vol. 315, # 9 p. 783 - 790
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran 1.2: tetrahydrofuran 2.1: MnO2 / CH2Cl2 3.1: aq. HCl View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 5 p. 1309 - 1311
反应条件
1: MnO2 / CH2Cl2 2: aq. HCl View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 5 p. 1309 - 1311
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran 1.2: tetrahydrofuran 2.1: MnO2 / CH2Cl2 3.1: aq. HCl View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 5 p. 1309 - 1311
反应条件
1: 86 percent / CrO3 / acetone / 3 h / -30 - 20 °C 2: 56 percent / aq. NH4OH / 110 °C View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 24 p. 3573 - 3577
