3-(4-甲基苯基)-1-苯工-1H-吡唑-4-羧酸合成路线 （共 5 条）
反应条件
trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl in acetone
T=20°C;
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea
Synlett, 2004 , # 13 p. 2299 - 2302
反应条件
1.1: 25 °C
1.2: dimethylformamide / 16 h / 20 °C
2.1: aq. Na2CO3
3.1: 97 percent / aq. NaHCO3; NaBr; trichloroisocyanuric acid / TEMPO / acetone / 20 °C
View Scheme
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea
Synlett, 2004 , # 13 p. 2299 - 2302
反应条件
1.1: 25 °C
1.2: dimethylformamide / 16 h / 20 °C
2.1: aq. Na2CO3
3.1: 97 percent / aq. NaHCO3; NaBr; trichloroisocyanuric acid / TEMPO / acetone / 20 °C
View Scheme
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea
Synlett, 2004 , # 13 p. 2299 - 2302
反应条件
1.1: 25 °C
1.2: dimethylformamide / 16 h / 20 °C
2.1: aq. Na2CO3
3.1: 97 percent / aq. NaHCO3; NaBr; trichloroisocyanuric acid / TEMPO / acetone / 20 °C
View Scheme
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea
Synlett, 2004 , # 13 p. 2299 - 2302
反应条件
1: sodium acetate / ethanol / 3 h / 50 - 60 °C
2: trichlorophosphate / 6 h / 50 - 60 °C / Cooling
3: sodium chlorite; aminosulfonic acid / acetone / 5 h / 40 - 50 °C
View Scheme
参考文献
Li, Xi; Lu, Xiang; Xing, Man; Yang, Xian-Hui; Zhao, Ting-Ting; Gong, Hai-Bin; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3589 - 3593
