S-(4-硝基苄基)-6-硫肌苷合成路线 （共 12 条）
反应条件
1: 6-chloro-9-(β-D-ribofuranosyl)-purine With pyridine; trityl resin 48 h; 2: 4-nitrobenzyl mercaptan With triethylamine in methanol T=55°C; 5 h; 3: With tri-iso-propylsilane; trifluoroacetic acid in dichloromethane 0.166667 h;
参考文献
Yadav, Vikas; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Guarcello, Vincenzo; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1987 - 1996
反应条件
1.1: 94 percent / hexamethyldisilazane; Me3SiCl; trimethylsilyl triflate / acetonitrile / 2.5 h / Heating 2.1: 36 percent / NH3 / methanol / 20 °C 3.1: trityl resin; pyridine / 48 h 3.2: Et3N / methanol / 5 h / 55 °C 3.3: 94 percent / triisopropylsilane; trifluoroacetic acid / CH2Cl2 / 0.17 h View Scheme
参考文献
Yadav, Vikas; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Guarcello, Vincenzo; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1987 - 1996
反应条件
1.1: 94 percent / hexamethyldisilazane; Me3SiCl; trimethylsilyl triflate / acetonitrile / 2.5 h / Heating 2.1: 36 percent / NH3 / methanol / 20 °C 3.1: trityl resin; pyridine / 48 h 3.2: Et3N / methanol / 5 h / 55 °C 3.3: 94 percent / triisopropylsilane; trifluoroacetic acid / CH2Cl2 / 0.17 h View Scheme
参考文献
Yadav, Vikas; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Guarcello, Vincenzo; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1987 - 1996
反应条件
1.1: 36 percent / NH3 / methanol / 20 °C 2.1: trityl resin; pyridine / 48 h 2.2: Et3N / methanol / 5 h / 55 °C 2.3: 94 percent / triisopropylsilane; trifluoroacetic acid / CH2Cl2 / 0.17 h View Scheme
参考文献
Yadav, Vikas; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Guarcello, Vincenzo; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1987 - 1996
反应条件
1: ethanol / 1 h / 100 °C / Microwave irradiation 2: potassium carbonate / ethanol / 1 h / Microwave irradiation View Scheme
参考文献
Niu, Hong-Ying; Xia, Chao; Qu, Gui-Rong; Wu, Shan; Jiang, Yi; Jin, Xin; Guo, Hai-Ming
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 45 - 49
反应条件
potassium carbonate in ethanol 1 h; Microwave irradiation;
参考文献
Niu, Hong-Ying; Xia, Chao; Qu, Gui-Rong; Wu, Shan; Jiang, Yi; Jin, Xin; Guo, Hai-Ming
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 45 - 49
反应条件
in water; isopropyl alcohol 2 h; Irradiationdeoxygenated solution; other solvent; Mechanism;
参考文献
Fleming, Steven A.; Rawlins, David B.; Robins, Morris J.
Tetrahedron Letters, 1990 , vol. 31, # 35 p. 4995 - 4998
反应条件
in water; isopropyl alcohol 2 h; Irradiationdeoxygenated solution; other solvent; Mechanism;
参考文献
Fleming, Steven A.; Rawlins, David B.; Robins, Morris J.
Tetrahedron Letters, 1990 , vol. 31, # 35 p. 4995 - 4998
反应条件
5 h; Irradiationother solvent, additives, other substrates; Product distributionMechanismQuantum yield;
参考文献
Fleming, Steven A.; Rawlins, David B.; Samano, Vicente; Robins, Morris J.
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5968 - 5976
反应条件
5 h; Irradiationother solvent, additives, other substrates; Product distributionMechanismQuantum yield;
参考文献
Fleming, Steven A.; Rawlins, David B.; Samano, Vicente; Robins, Morris J.
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5968 - 5976
