2,2-二甲基-2,3-二羟基-1-苯并呋喃-7-甲醛合成路线 （共 7 条）
反应条件
hydrogenchloride; sodium borohydride; sodium chloride in ethanol; water
参考文献
FMC Corporation
Patent: US4748186 A1, 1988 ;
反应条件
sodium chloride in tetrahydrofuran; N-methyl-acetamide
参考文献
FMC Corporation
Patent: US4748186 A1, 1988 ;
反应条件
dipyridinium dichromate in dichloromethane
T=40°C; Oxidation;
参考文献
Plobeck; Delorme; Wei; Yang; Zhou; Schwarz; Gawell; Gagnon; Pelcman; Schmidt; Yue; Walpole; Brown; Labare; Payza; St-Ogne; Kamassah; Morin; Projean; Ducharme; Roberts
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3878 - 3894
反应条件
1: pyridine / CH2Cl2 / 1 h / 25 °C
2: Et3N; Pd(OAc)2; bis-diphenylphosphinoferrocene / methanol; dimethylsulfoxide / 16 h / 70 °C
3: DIBAl / toluene / 0.5 h / -78 °C
4: pyridinium dichromate / CH2Cl2 / 40 °C
View Scheme
参考文献
Plobeck; Delorme; Wei; Yang; Zhou; Schwarz; Gawell; Gagnon; Pelcman; Schmidt; Yue; Walpole; Brown; Labare; Payza; St-Ogne; Kamassah; Morin; Projean; Ducharme; Roberts
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3878 - 3894
反应条件
1: DIBAl / toluene / 0.5 h / -78 °C
2: pyridinium dichromate / CH2Cl2 / 40 °C
View Scheme
参考文献
Plobeck; Delorme; Wei; Yang; Zhou; Schwarz; Gawell; Gagnon; Pelcman; Schmidt; Yue; Walpole; Brown; Labare; Payza; St-Ogne; Kamassah; Morin; Projean; Ducharme; Roberts
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3878 - 3894
反应条件
1: Et3N; Pd(OAc)2; bis-diphenylphosphinoferrocene / methanol; dimethylsulfoxide / 16 h / 70 °C
2: DIBAl / toluene / 0.5 h / -78 °C
3: pyridinium dichromate / CH2Cl2 / 40 °C
View Scheme
参考文献
Plobeck; Delorme; Wei; Yang; Zhou; Schwarz; Gawell; Gagnon; Pelcman; Schmidt; Yue; Walpole; Brown; Labare; Payza; St-Ogne; Kamassah; Morin; Projean; Ducharme; Roberts
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3878 - 3894
反应条件
1: in methanol; ethanol
3 h;
2: With sodium tetrahydroborate in methanol
3: With water
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2007/53131 A2, 2007 ;
Location in patent: Page/Page column 160 ;
WO 2007/053131 A2
