3-氯-4-甲氧基苯甲酸合成路线 （共 32 条）
反应条件
N-chloro-succinimide; trifluoroacetic acid T=70°C; 3 h;
参考文献
AKAAL PHARMA PTY LTD; GILL, Gurmit, S.; GROBELNY, Damian, W.
Patent: WO2010/42998 A1, 2010 ;
Location in patent: Page/Page column 51; 52 ;
WO 2010/042998 A1
反应条件
sodium hydroxide Heating;
参考文献
Riggs; Nichols; Foreman; Truex
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
反应条件
1: 93 percent / concd. H2SO4 / 5 h / Heating 2: K2CO3 / acetone / 16 h / Heating 3: 91.8 percent / aq. NaOH / Heating View Scheme
参考文献
Riggs; Nichols; Foreman; Truex
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
反应条件
1: K2CO3 / acetone / 16 h / Heating 2: 91.8 percent / aq. NaOH / Heating View Scheme
参考文献
Riggs; Nichols; Foreman; Truex
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1887 - 1891
反应条件
1: 1) KHMDS, 2) trisyl azide / 1) THF, toluene, -78 deg C, 20 min, 2) THF, toluene, -78 deg C, 2 min 2: LiOH, H2O2 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme
参考文献
Pearson, Anthony J.; Zhang, Penglie
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9603 - 9604
反应条件
in methanol; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=120°C; 15 h;
参考文献
El-Gamal, Mohammed I.; Choi, Hong Seok; Yoo, Kyung Ho; Baek, Daejin; Oh, Chang-Hyun
Chemical Biology and Drug Design, 2013 , vol. 82, # 3 p. 336 - 347
反应条件
chromic acid; acetic acid
参考文献
Peratoner; Ortoleva
Gazzetta Chimica Italiana, 1898 , vol. 28 I, p. 226
反应条件
lithium aluminium tetrahydride
参考文献
Silk; Aubry; Lonergan; Macaulay
Chemosphere, 2001 , vol. 44, # 7 p. 1603 - 1616
反应条件
1: chlorine 2: magnesium; diethyl ether View Scheme
参考文献
Paty; Quelet
Bulletin de la Societe Chimique de France, 1944 , vol. <5> 11, p. 505,509
Full Text Show Details
Paty
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1942 , vol. 214, p. 910
Bulletin de la Societe Chimique de France, 1944 , vol. <5> 11, p. 505,510
反应条件
sulfuric acid; sodium nitrite
参考文献
Gattermann
Chemische Berichte, 1899 , vol. 32, p. 1119
Justus Liebigs Annalen der Chemie, 1888 , vol. 244, p. 55
