2-(5-三氟甲基-1H-吲哚-3-基)乙酸合成路线 (共 2 条)
反应条件
sodium hydroxide; sulfuric acid in methanol; water; ethyl acetate
参考文献
Fujiwara, Shinya; Ozaki, Tomokazu; Kozono, Toshiro; Hattori, Kunihiro; Esaki, Toru
Patent: US2003/162724 A1, 2003 ;
反应条件
1: diethyl ether / 0.25 h
2: NaH2PO2; palladium on activated charcoal / water; 1,4-dioxane / 125 °C
3: lithium hydroxide hydrate; water / tetrahydrofuran; methanol
View Scheme
参考文献
GILEAD SCIENCES, INC.; BONDY, Steven S.; CANNIZZARO, Carina E.; CHOU, Chien-hung; HALCOMB, Randall L.; HU, Yunfeng Eric; LINK, John O.; LIU, Qi; SCHROEDER, Scott D.; TSE, Winston C.; ZHANG, Jennifer R.
Patent: WO2013/6738 A1, 2013 ;