2-乙氧亚甲基乙酰乙酸乙酯合成路线 （共 63 条）
反应条件
1: 1-methylguanidine hydrochloride With sodium ethanolate 0.5 h; 2: ethyl ethoxymethyleneacetoacetate 1 h; Heating;
参考文献
Vardanyan, Ruben S.; Danagulyan, Gevork G.; Mkrtchyan, Armen D.; Hruby, Victor J.
Heterocyclic Communications, 2011 , vol. 17, # 3-4 p. 129 - 133
反应条件
1: ethanolic sodium ethylate 2: NH3 View Scheme
参考文献
Chi; Wu
Huaxue Xuebao, 1957 , vol. 23, p. 145,150
Scientia Sinica (English Edition), 1957 , vol. 6, p. 853
Chem.Abstr., 1958 , p. 14626
参考文献
Mitter; Palit
Journal of the Indian Chemical Society, 1925 , vol. 2, p. 67
Chem. Zentralbl., 1926 , vol. 97, # I p. 118
反应条件
sodium ethanolate in ethanol 30 min, room temp.; 24 h, 4 deg C;
参考文献
Kristen, Helmut; Raddatz, Marianne
Zeitschrift fuer Chemie (Stuttgart, Germany), 1981 , vol. 21, # 3 p. 101
反应条件
in diethyl ether 18 h; Ambient temperature; Yield given;
参考文献
Nagarajan, Kuppuswamy; Arya, Vishwa Prakash; Shenoy, Sharada J.
Journal of Chemical Research, Miniprint, 1986 , # 5 p. 1401 - 1443
反应条件
1: 55 percent / NaOEt / ethanol / 6 h / Heating 2: 85 percent / aq. NaOH / tetrahydrofuran View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: ethanolic sodium ethylate 2: ethanolic KOH View Scheme
参考文献
Chi; Wu
Huaxue Xuebao, 1957 , vol. 23, p. 145,150
Scientia Sinica (English Edition), 1957 , vol. 6, p. 853
Chem.Abstr., 1958 , p. 14626
反应条件
sodium acetate in DMF (N,N-dimethyl-formamide) T=80°C; 4 h;
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; Ihara Chemical Industry Co., Ltd.
Patent: EP1439169 A1, 2004 ;
Location in patent: Page 95 ;
反应条件
sodium acetate in N,N-dimethyl-formamide T=80°C; 3.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; POONI, Parminder, Kaur; MERCHANT, Kevin, John; KERR, Catrina, Morvern; HARRISON, David
Patent: WO2011/83316 A1, 2011 ;
Location in patent: Page/Page column 53 ;
WO 2011/083316 A1
反应条件
triethylamine in ethanol 48 h; Reflux;
参考文献
MERCK PATENT GMBH; SCHIEMANN, Kai; SCHULTZ, Melanie; STAEHLE, Wolfgang; KOBER, Ingo; WIENKE, Dirk; KRIER, Mireille
Patent: WO2010/63352 A1, 2010 ;
Location in patent: Page/Page column 88-89 ;
WO 2010/063352 A1
