7-羟基-3,4-二氢-1H-2-萘酮合成路线 （共 7 条）
反应条件
1: With potassium carbonate in 1-methyl-pyrrolidin-2-one T=180°C; 6 h; 2: T=20°C; 12 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/80968 A1, 2004 ;
Location in patent: Page 46 ;
WO 2004/080968 A1
反应条件
aluminum tri-bromide; cyclohexane in various solvent(s) T=25°C; 24 h;
参考文献
Ostashevskaya; Koltunov; Repinskaya
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 10 p. 1474 - 1477
反应条件
1: Solid phase reaction; 2: With trifluoroacetic acid in dichloromethane T=20°C; cleavage; 0.5 h;
参考文献
Iso, Yasuyoshi; Shindo, Hirohisa; Hamana, Hiroshi
Tetrahedron, 2000 , vol. 56, # 30 p. 5353 - 5361
反应条件
dihydrogen peroxide; hydrogen fluoride; SbF5 T=-50°C; 0.0333333 h; MechanismProduct distribution;
参考文献
Gesson, Jean-Pierre; Jacquesy, Jean-Claude; Jouannetaud, Marie-Paule; Morellet, Guy
Tetrahedron Letters, 1983 , vol. 24, # 30 p. 3095 - 3098
反应条件
1.1: thionyl chloride / dimethylformamide; CH2Cl2 / 0.5 h / 20 °C 2.1: dimethylformamide; CH2Cl2 / 2 h / 20 °C 3.2: TFA / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Iso, Yasuyoshi; Shindo, Hirohisa; Hamana, Hiroshi
Tetrahedron, 2000 , vol. 56, # 30 p. 5353 - 5361
参考文献
Schaetzle, Michael A.; Flemming, Stephan; Husain, Syed Masood; Richter, Michael; Guenther, Stefan; Mueller, Michael
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2643 - 2646
反应条件
1.1: dimethylformamide; CH2Cl2 / 2 h / 20 °C 2.2: TFA / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Iso, Yasuyoshi; Shindo, Hirohisa; Hamana, Hiroshi
Tetrahedron, 2000 , vol. 56, # 30 p. 5353 - 5361
