3-甲基吡咯-2,4-二羧酸二甲酯合成路线 （共 10 条）
反应条件
1: methyl 4-methyl-1H-pyrrole-3-carboxylate; 2,2,2-trichloroacetyl chloride With AlCl3, aluminium chloride in 1,2-dichloro-ethane T=-40 - 20°C; 89 h; 2: sodium methylate in methanol pH=10; 1 h;
参考文献
Bristol Myers Squibb Company
Patent: US6982265 B1, 2006 ;
Location in patent: Page/Page column 33 ;
反应条件
1: sodium hydride / tetrahydrofuran; dimethylsulfoxide 2: AlCl3 3: NaOMe View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
反应条件
1: AlCl3 2: NaOMe View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
参考文献
Nicolaus; Mangoni
Gazzetta Chimica Italiana, 1955 , vol. 85, p. 1378,1392
Annali di Chimica (Rome, Italy), 1956 , vol. 46, p. 847,855
反应条件
1: ethanolic KOH 2: methanol. HCl View Scheme
参考文献
Nicolaus; Mangoni
Gazzetta Chimica Italiana, 1955 , vol. 85, p. 1378,1392
Annali di Chimica (Rome, Italy), 1956 , vol. 46, p. 847,855
反应条件
1: Raney nickel; aq.-ethanolic NaOH / Hydrogenation 2: ethanolic KOH 3: methanol. HCl View Scheme
参考文献
Nicolaus; Mangoni
Gazzetta Chimica Italiana, 1955 , vol. 85, p. 1378,1392
Annali di Chimica (Rome, Italy), 1956 , vol. 46, p. 847,855
反应条件
1: Ph2P(O)ONH2; NaH / dimethylformamide 2: Heating View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
反应条件
O-(diphenyl-phosphinyl)hydroxylamine; sodium hydride in N,N-dimethyl-formamide
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
反应条件
1: Ph2P(O)ONH2; NaH / dimethylformamide 2: Heating 3: POCl3 / Heating View Scheme
参考文献
Borzilleri, Robert M.; Cai, Zhen-Wei; Ellis, Christopher; Fargnoli, Joseph; Fura, Aberra; Gerhardt, Tracy; Goyal, Bindu; Hunt, John T.; Mortillo, Steven; Qian, Ligang; Tokarski, John; Vyas, Viral; Wautlet, Barri; Zheng, Xioping; Bhide, Rajeev S.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1429 - 1433
