2,2-二甲基-苯并二氢吡喃-4-酮合成路线 (共 66 条)
反应条件
in hexane; sulfuric acid; ethyl acetate
参考文献
PFIZER INC.
Patent: EP230379 B1, 1991 ;
反应条件
1: With ammonium acetate; sodium cyanoborohydride in methanol 24 h; 2: With hydrogenchloride in methanol; water pH=< 1; 3: With potassium hydroxide in methanol; water
参考文献
PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2006/108103 A1, 2006 ;
Location in patent: Page/Page column 123 ;
参考文献
v.Auwers; Mauss
Chemische Berichte, 1928 , vol. 61, p. 2549
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Skraup; Beng
Chemische Berichte, 1927 , vol. 60, p. 946
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v. Auwers
Chemische Berichte, 1928 , vol. 61, p. 411,415
反应条件
piperidine
0.166667 h; Neat (no solvent)Microwave irradiation;
参考文献
Tripathi; Koul; Taneja
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 2 p. 301 - 304
反应条件
cesium fluoride in tetrahydrofuran
T=125°C;
参考文献
Dubrovskiy, Anton V.; Larock, Richard C.
Tetrahedron, 2013 , vol. 69, # 13 p. 2789 - 2798
反应条件
oxygen; potassium carbonate; palladium diacetate in ethanol; water
T=35°C; Wacker-type oxidative cyclization; P=760.051 Torr; 24 h;
参考文献
Zhang, Zuhui; Pan, Chongfeng; Wang, Zhiyong
Chemical Communications, 2007 , # 44 p. 4686 - 4688
反应条件
potassium hydroxide in cyclohexane; water
T=20°C; photo-Fries rearrangement; 1 h; Inert atmosphereIrradiation;
参考文献
Lopez, Cecilia Samaniego; Erra-Balsells, Rosa; Bonesi, Sergio M.
Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4387 - 4390
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=3800 Torr; Ambient temperature;
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=3800 Torr; Ambient temperature;
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
反应条件
formic acid; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide
T=60°C; 0.833333 h;
参考文献
Koever, Jozsef; Antus, Sandor
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005 , vol. 60, # 7 p. 792 - 796