2,2-联噻吩-5-乙醛合成路线 （共 24 条）
反应条件
trichlorophosphate Vilsmeier formylation;
参考文献
Raimundo, Jean-Manuel; Blanchard, Philippe; Gallego-Planas, Nuria; Mercier, Nicolas; Ledoux-Rak, Isabelle; Hierle, Rolland; Roncali, Jean
Journal of Organic Chemistry, 2002 , vol. 67, # 1 p. 205 - 218
反应条件
N,N-dimethyl-formamide; toluene; trichlorophosphate anschliessendes Behandeln mit wss. Natriumacetat-Loesung;
参考文献
Industrial Technology Research Institute
Patent: US5602170 A1, 1997 ;
反应条件
1: 2-(5-bromothienyl)-2-thiophene With magnesium in tetrahydrofuran Inert atmosphereReflux; 2: N,N-dimethyl-formamide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water Cooling with ice;
参考文献
Deng, Huayun; Fang, Ye; He, Mingqian; Hu, Haibei; Niu, Weijun; Sun, Haiyan
Patent: US2012/22116 A1, 2012 ;
Location in patent: Page/Page column 55 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=80 - 90°C; Stille coupling; 24 h;
参考文献
Ismail, Mohamed A.
Journal of Chemical Research, 2006 , # 11 p. 733 - 737
反应条件
palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in water; acetonitrile T=25°C; Suzuki Coupling; Inert atmosphere;
参考文献
Lin, Jinshun; Jin, Xiuli; Bu, Yiwen; Cao, Deliang; Zhang, Nannan; Li, Shangfu; Sun, Qinsheng; Tan, Chunyan; Gao, Chunmei; Jiang, Yuyang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 48 p. 9734 - 9746
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene 18 h; Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2003/101381 A2, 2003 ;
Location in patent: Page 81 ;
WO 03/101381 A2
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=60°C; 16 h;
参考文献
Crisp, Geoffrey T.
Synthetic Communications, 1989 , vol. 19, # 1, 2 p. 307 - 316
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; toluene T=120°C; Suzuki-Miyaura Coupling; 72 h; Inert atmosphere;
参考文献
Lu, Zhen; Li, Cuihong; Fang, Tao; Li, Guangwu; Bo, Zhishan
Journal of Materials Chemistry A, 2013 , vol. 1, # 26 p. 7657 - 7665
反应条件
1: thien-2-ylmagnesium bromide With bismuth(III) chloride 2: 5-Bromothiophene-2-carboxaldehyde With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 20 h; Heating;
参考文献
Kamal, Marwan R.; Al-Taweel, Samir A.; El-Abadelah, Mustafa M.; Ajaj, Khalid M. Abu
Phosphorus, Sulfur and Silicon and the Related Elements, 1997 , vol. 126, p. 65 - 74
