3,3-二苯基四氢呋喃-2-亚基二甲基溴化胺合成路线 （共 12 条）
反应条件
sodium carbonate in tetrahydrofuran; water; toluene T=0°C; 12 h;
参考文献
WO2008/53352 A2, ;
Page/Page column 42 ;
反应条件
sodium carbonate; dimethyl amine in water; toluene
参考文献
EP1325912 A1, ;
EP 1325912 A1
反应条件
sodium carbonate; dimethyl amine in water; toluene
参考文献
EP1325912 A1, ;
EP 1325912 A1
反应条件
1: 4-Bromo-2,2-diphenylbutyric acid With oxalyl dichloride in dichloromethane 2 h; Heating / reflux; 2: dimethyl amine With sodium carbonate in water; toluene T=-5 - 0°C; 1 h; Product distribution / selectivity;
参考文献
WO2005/75455 A2, ;
Page/Page column 122-123 ;
反应条件
oxalyl dichloride; triethylamine; N,N-dimethyl-formamide in tetrahydrofuran; chloroform; toluene T=-10 - 0°C; 1.5 h; Product distribution / selectivity;
参考文献
WO2005/75455 A2, ;
Page/Page column 70; 112 ;
反应条件
thionyl chloride; dimethyl amine in chloroform; water; toluene
参考文献
US5994372 A1, ;
US 5994372 A
反应条件
1: thionyl chloride; dimethylformamide / CHCl3 / 4 h / Heating 2: Na2CO3 / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 21 p. 5275 - 5279
反应条件
1: hydrogen bromide; acetic acid / 48 h / 20 °C 2: thionyl chloride / chloroform / 4 h / |Reflux 3: sodium carbonate / water; toluene / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 19 p. 5259 - 5263
反应条件
1: 4-(4-chlorophenyl)-piperidin-4-ol With sodium carbonate; potassium iodide in 4-hydroxymethyl-1,3-dioxolane 0.25 h; 2: N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide in 4-hydroxymethyl-1,3-dioxolane T=60°C; 2 h; 3: With hydrogenchloride in 4-hydroxymethyl-1,3-dioxolane; isopropyl alcohol 0.333333 h;
参考文献
INSTITUT UNIVERSITARI DE CIENCIA I TECNOLOGIA
Patent: WO2008/80601 A2, 2008 ;
Location in patent: Page/Page column 10 ;
反应条件
potassium iodide; sodium carbonate in hydrogenchloride; isopropyl alcohol; acetone; toluene
参考文献
Adolor Corporation
Patent: US5798093 A1, 1998 ;
