4-吗啉丙酸 b-氧代-乙酯合成路线 （共 12 条）
反应条件
potassium hydroxide in ethanol Ambient temperature;
参考文献
Katagi; Aoki; Kashiwagi; Ohata; Kohno; Murata; Inoi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4878 - 4888
反应条件
trichlorophosphate 1.) s-dichloroethane, rt, 30 min; 2.) s-dichloroethane, 5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Roma, G.; Ermili, A.; Braccio, M. Di; Mazzei, M.
Farmaco, Edizione Scientifica, 1982 , vol. 37, # 11 p. 747 - 758
反应条件
trichlorophosphate 1.) chlorobenzene, r.t., 30 min, 2.) chlorobenzene, 130 deg C, 4 h; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Roma, Giorgio; Di Braccio, Mario; Grossi, Giancarlo; Marzano, Cristina; Simonato, Morena; Bordin, Franco
Farmaco, 1998 , vol. 53, # 7 p. 494 - 503
反应条件
in diethyl ether
T=-10°C; 0.5 h;
参考文献
Katagi; Aoki; Kashiwagi; Ohata; Kohno; Murata; Inoi
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4878 - 4888
反应条件
hydrogenchloride; sodium hydrogencarbonate; triethylamine in N-methyl-acetamide; dichloromethane; water
参考文献
Rhone-Poulenc Sante
Patent: US4407797 A1, 1983 ;
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) in toluene
T=60°C; P=760.051 Torr; 12 h;
参考文献
Zhang, Zhenhua; Liu, Yiyang; Ling, Lin; Li, Yuxue; Dong, Yian; Gong, Mingxing; Zhao, Xiaokun; Zhang, Yan; Wang, Jianbo
Journal of the American Chemical Society, 2011 , vol. 133, # 12 p. 4330 - 4341
反应条件
in chloroform
T=20°C; 24 h;
参考文献
Nakaike, Yumi; Taba, Noriko; Itoh, Shinobu; Tobe, Yoshito; Nishiwaki, Nagatoshi; Ariga, Masahiro
Bulletin of the Chemical Society of Japan, 2007 , vol. 80, # 12 p. 2413 - 2417
反应条件
acetic acid
2 h; Heating;
参考文献
Armati, Antonella; Ruggieri, Pietro De; Rossi, Elisabetta; Stradi, Riccardo
Synthesis, 1986 , # 7 p. 573 - 576
反应条件
thionyl chloride
1.) 2 h, reflux, 2.) 30 min, 20 degC;
参考文献
Bartsch, Herbert; Erker, Thomas
Liebigs Annalen der Chemie, 1989 , p. 177 - 180
反应条件
1: 65 percent
2: 56 percent / 50percent CH3COOH / 2 h / Heating
View Scheme
参考文献
Armati, Antonella; Ruggieri, Pietro De; Rossi, Elisabetta; Stradi, Riccardo
Synthesis, 1986 , # 7 p. 573 - 576
