吩噻嗪基-2-氨基甲酸乙酯合成路线 （共 8 条）
反应条件
1: 73 percent / benzene / 3 h / Heating 2: 55 percent / 1,2-dichloro-ethane / 3.5 h / Heating View Scheme
参考文献
Gritsenko, A. N.; Skoldinov, A. P.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 4 p. 279 - 282
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 4 p. 485 - 488
反应条件
1: 73 percent / benzene / 3 h / Heating 2: 3.5 h / Heating View Scheme
参考文献
Gritsenko, A. N.; Skoldinov, A. P.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 4 p. 279 - 282
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 4 p. 485 - 488
反应条件
1: NaOH / ethanol / 1.5 °C / Heating 2: 83 percent / HCl; H2O View Scheme
参考文献
Richards; Pieniaszek Jr.; Shatzmiller; Page; Blom; Read; Davidson; Confalone
Xenobiotica, 1997 , vol. 27, # 2 p. 217 - 229
反应条件
1: 1.) K2CO3, Cu, KI, 2.) 7N HCl / 1.) nitrobenzene, reflux, 20 h, 2.) reflux, 8 h
2: H2 / 5percent Pd/C / ethanol
3: Na2CO3 / ethanol; H2O / 0.33 h
4: sulfur, I2 / toluene / 8 h / Heating
View Scheme
参考文献
Sparatore
Farmaco, 1994 , vol. 49, # 1 p. 5 - 17
反应条件
1: 1.) K2CO3, Cu, KI, 2.) 7N HCl / 1.) nitrobenzene, reflux, 20 h, 2.) reflux, 8 h
2: H2 / 5percent Pd/C / ethanol
3: Na2CO3 / ethanol; H2O / 0.33 h
4: sulfur, I2 / toluene / 8 h / Heating
View Scheme
参考文献
Sparatore
Farmaco, 1994 , vol. 49, # 1 p. 5 - 17
反应条件
1: H2 / 5percent Pd/C / ethanol
2: Na2CO3 / ethanol; H2O / 0.33 h
3: sulfur, I2 / toluene / 8 h / Heating
View Scheme
参考文献
Sparatore
Farmaco, 1994 , vol. 49, # 1 p. 5 - 17
反应条件
iodine; sulfur in toluene
8 h; Heating; Yield given;
参考文献
Sparatore
Farmaco, 1994 , vol. 49, # 1 p. 5 - 17
反应条件
acetate buffer in water
T=60°C; var. pH, var. buffers and buffers concentrations, ΔEa, ΔS(excit.); Rate constantProduct distributionThermodynamic data;
参考文献
King; Sigvardson; Dudzinski; Torosian
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 6 p. 586 - 591
