2-氯-5-甲基苯并[d]噁唑合成路线 （共 4 条）
反应条件
1: dimethylsulfoxide; propan-2-ol 2: K2CO3 3: aq. HCl View Scheme
参考文献
Moeller,H.
Justus Liebigs Annalen der Chemie, 1971 , vol. 749, p. 1 - 11
反应条件
thionyl chloride; N,N-dimethyl-formamide
T=20°C; 0.5 h;
参考文献
GALLEON PHARMACEUTICALS, INC.
Patent: US2011/224269 A1, 2011 ;
Location in patent: Page/Page column 21 ;
反应条件
1: ethanol
2: SOCl2; DMF / toluene
View Scheme
参考文献
Yamazaki, Yukiyoshi; Abe, Kazutoyo; Toma, Tsutomu; Nishikawa, Masahiro; Ozawa, Hidefumi; Okuda, Ayumu; Araki, Takaaki; Oda, Soichi; Inoue, Keisuke; Shibuya, Kimiyuki; Staels, Bart; Fruchart, Jean-Charles
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4689 - 4693
反应条件
1: H2 / Pd-C / ethanol
2: KOH / ethanol / Heating
3: PCl5 / toluene / Heating
View Scheme
参考文献
Yoshida, Satoshi; Watanabe, Takashi; Sato, Yasuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 10 p. 3515 - 3523
