2,3-二甲基-4-硝基吡啶-N-氧化物合成路线 （共 41 条）
反应条件
sulfuric acid; nitric acid T=100°C; 5 h;
参考文献
Tanga; Bupp; Tochimoto
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 717 - 727
反应条件
1: in tetrahydrofuran T=-60°C; Inert atmosphere; 2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran T=-60 - 20°C; Inert atmosphere; regioselective reaction;
参考文献
Zhang, Fang; Duan, Xin-Fang
Organic Letters, 2011 , vol. 13, # 22 p. 6102 - 6105
反应条件
sodium hydroxide; sulfuric acid; nitric acid in water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6002011 A1, 1999 ;
反应条件
nitric acid in acetic acid T=80°C; 33 h;
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
参考文献
Zeneca Limited
Patent: US5300478 A1, 1994 ;
反应条件
1: dihydrogen peroxide; acetic acid / 24 h / |Reflux 2: nitric acid; sulfuric acid / 24 h / 90 °C View Scheme
参考文献
Ma, Chao; Wu, Anhui; Wu, Yongqi; Ren, Xuhong; Cheng, Maosheng
Archiv der Pharmazie, 2013 , vol. 346, # 12 p. 891 - 900
反应条件
potassium carbonate 2 h; Heating;
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C 2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C View Scheme
参考文献
Hoffman-La Roche Inc.
Patent: US4766133 A1, 1988 ;
反应条件
tetrabutylammomium bromide in methanol
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4920230 A1, 1990 ;
反应条件
hydrogenchloride; sodium chloride; (benzyl)-tri-(butyl)-ammonium chloride in water; acetonitrile 12 h; Heating / reflux;
参考文献
US2004/63957 A1, ;
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