2-氯-3-羟基-4-甲氧基苯甲醛合成路线 （共 21 条）
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
参考文献
Hornbaker; Burger
Journal of the American Chemical Society, 1955 , vol. 77, p. 5314,5317
反应条件
1: hexamethylenetetramine; CHCl3 / und Erhitzen des Reaktionsprodukts mit wss.Essigsaeure 2: aqueous HBr View Scheme
参考文献
Hornbaker; Burger
Journal of the American Chemical Society, 1955 , vol. 77, p. 5314,5317
反应条件
1: acetic acid / 60 °C 2: hexamethylenetetramine; CHCl3 / und Erhitzen des Reaktionsprodukts mit wss.Essigsaeure 3: aqueous HBr View Scheme
参考文献
Hornbaker; Burger
Journal of the American Chemical Society, 1955 , vol. 77, p. 5314,5317
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 3: 97 percent / 12N aq. HCl 4: 96 percent / dimethylsulfoxide / 1.25 h 5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 3: 97 percent / 12N aq. HCl 4: 96 percent / dimethylsulfoxide / 1.25 h 5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 6: 19 percent / 2.5 h / Heating 7: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
potassium carbonate in acetonitrile
参考文献
Rohm and Haas Company
Patent: US5866513 A1, 1999 ;
反应条件
sodium hydroxide in chloroform; water; acetonitrile
参考文献
Eisai Co., Ltd.
Patent: US5292521 A1, 1994 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide 0.0833333 h; Heating;
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
in N-methyl-acetamide; tetrachloromethane; ethanol; acetonitrile
参考文献
SmithKline Corporation
Patent: US4104379 A1, 1978 ;
