5-氯-2-羟基-3-硝基-(1,1-联苯)-3-羧酸合成路线 （共 6 条）
反应条件
sulfuric acid; nitric acid; acetic acid T=20°C; 1 h;
参考文献
ASSIA CHEMICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.; AVDAGIC, Amir; BARAN, Phil, S.
Patent: WO2013/49605 A1, 2013 ;
Location in patent: Paragraph 0052 ;
反应条件
palladium diacetate; sodium carbonate in water T=50°C; 3.5 h; Inert atmosphere;
参考文献
WO2013/49605 A1, ;
Paragraph 0055 ;
反应条件
1: sodium carbonate; palladium diacetate / water / 4 h / 50 °C / |Inert atmosphere 2: sulfuric acid; nitric acid; acetic acid / 1 h / 20 °C View Scheme
反应条件
1: sodium carbonate; palladium diacetate / water / 4 h / 50 °C / |Inert atmosphere 2: sulfuric acid; nitric acid; acetic acid / 1 h / 20 °C View Scheme
反应条件
1: acetic acid; bromine / 3.5 h / 5 - 20 °C 2: sodium carbonate; palladium diacetate / water / 3.5 h / 50 °C / |Inert atmosphere View Scheme
反应条件
palladium 10 on activated carbon; hydrogen; triethylamine in methanol T=20°C; P=7500.75 Torr; 21 h; Autoclave;
参考文献
ASSIA CHEMICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.; AVDAGIC, Amir; BARAN, Phil, S.
Patent: WO2013/49605 A1, 2013 ;
Location in patent: Paragraph 0058 ;
