N-[苯基-(甲苯-4-磺酰基)甲基]甲酰胺合成路线 （共 4 条）
反应条件
triethylamine; trichlorophosphate in tetrahydrofuran T=0°C; Yield given;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/14900 A1, 2004 ;
Location in patent: Page 27 ;
WO 2004/014900 A1
反应条件
chloro-trimethyl-silane in toluene; acetonitrile
T=50°C; 5 h;
参考文献
Sisko, Joseph; Mellinger, Mark; Sheldrake, Peter W.; Baine, Neil H.
Tetrahedron Letters, 1996 , vol. 37, # 45 p. 8113 - 8116
参考文献
van Leusen,A.M. et al.
Journal of Organic Chemistry, 1977 , vol. 42, # 7 p. 1153 - 1159
反应条件
1: benzaldehyde; formamide With chloro-trimethyl-silane in toluene; acetonitrile
T=50°C; 5 h;
2: toluene-4-sulfonic acid T=50°C; 4 h;
参考文献
Morana, Fabio; Basso, Andrea; Bella, Marco; Riva, Renata; Banfi, Luca
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2199 - 2210
