2,4,6-三氯嘧啶合成路线

参考文献

F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.
Patent: WO2009/66084 A1, 2009 ;
Location in patent: Page/Page column 65-66 ;
WO 2009/066084 A1

3764-01-02,4,6-三氯嘧啶+

57260-71-61-Boc-哌嗪

1155306-28-74-(2,6-二氯嘧啶-4-基)哌嗪-1-羧酸叔丁酯+

1197341-88-0

参考文献

Ho, Koc-Kan; Beasley, James R.; Belanger, Laura; Black, Darcey; Chan, Jui-Hsiang; Dunn, David; Hu, Bing; Klon, Anthony; Kultgen, Steven G.; Ohlmeyer, Michael; Parlato, Susan M.; Ray, Peter C.; Pham, Quynhchi; Rong, Yajing; Roughton, Andrew L.; Walker, Tiffany L.; Wright, Jane; Xu, Kai; Xu, Yan; Zhang, Limei; Webb, Maria
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6027 - 6031

3764-01-02,4,6-三氯嘧啶

10132-07-74-氨基-2,6-二氯嘧啶+

56-05-32-氨基-4,6-二氯嘧啶

参考文献

Buettner
Chemische Berichte, 1903 , vol. 36, p. 2234
Full Text Show Details
Gabriel
Chemische Berichte, 1901 , vol. 34, p. 3363

3764-01-02,4,6-三氯嘧啶

56-05-32-氨基-4,6-二氯嘧啶

参考文献

Delia, Thomas J.; Meltsner, Bernard R.; Schomaker, Jennifer M.
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 5 p. 1259 - 1261

3764-01-02,4,6-三氯嘧啶+

7664-41-7氨气

10132-07-74-氨基-2,6-二氯嘧啶+

56-05-32-氨基-4,6-二氯嘧啶

参考文献

Buettner
Chemische Berichte, 1903 , vol. 36, p. 2227
Full Text Show Details
Gabriel
Chemische Berichte, 1901 , vol. 34, p. 3363

3764-01-02,4,6-三氯嘧啶+

75-04-7乙胺

10371-48-9+

70958-39-32,6-二氯-N-乙基-4-嘧啶胺

参考文献

Botta; Saladino; Anzini; Corelli
Nucleosides and Nucleotides, 1994 , vol. 13, # 8 p. 1769 - 1777

3764-01-02,4,6-三氯嘧啶+

3034-41-11-甲基-4-硝基咪唑

1208893-80-42,6-二氯-N-(1-甲基-1H-咪唑-4-基)嘧啶-4-胺

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED; ALMEIDA, Lynsie; CHUAQUI, Claudio, Edmundo; GUAN, Amy; IOANNIDIS, Stephanos; LAMB, Michelle; PENG, Bo; SU, Qibin
Patent: WO2010/20810 A1, 2010 ;
Location in patent: Page/Page column 66-67 ;
WO 2010/020810 A1

3764-01-02,4,6-三氯嘧啶+

79578-98-61-甲基-4-氨基咪唑

1208893-80-42,6-二氯-N-(1-甲基-1H-咪唑-4-基)嘧啶-4-胺

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CHUAQUI, Claudio, Edmundo; HUANG, Shan; IOANNIDIS, Stephanos; SHI, Jie; SU, Mei; SU, Qibin
Patent: WO2010/38060 A1, 2010 ;
Location in patent: Page/Page column 87 ;
WO 2010/038060 A1

3764-01-02,4,6-三氯嘧啶+

98-80-6苯硼酸

1666-86-0

参考文献

Isfahani, Amir Landarani; Mohammadpoor-Baltork, Iraj; Mirkhani, Valiollah; Khosropour, Ahmad R.; Moghadam, Majid; Tangestaninejad, Shahram; Kia, Reza
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 957 - 972

3764-01-02,4,6-三氯嘧啶

1666-86-0

参考文献

Alacid, Emilio; Najera, Carmen
Organic Letters, 2008 , vol. 10, # 21 p. 5011 - 5014