4,4-二氟-N-((1S)-3-氧代-1-苯基丙基)环己烷甲酰胺合成路线 (共 3 条)
反应条件
sodium tris(acetoxy)borohydride in ethyl acetate T=0 - 15°C; 2 h; Inert atmosphereLarge scale;
参考文献
Ahman, Jens; Birch, Melissa; Haycock-Lewandowski, Sarah J.; Long, James; Wilder, Alexander
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1104 - 1113
反应条件
1: With acetic acid in 1,2-dichloro-ethane T=20°C; 12 h; 2: With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane T=20°C; 12 h; Further stages.;
参考文献
Lou, Sha; Moquist, Philip N.; Schaus, Scott E.
Journal of the American Chemical Society, 2007 , vol. 129, # 49 p. 15398 - 15404
反应条件
sodium tetrahydroborate in methanol
T=0°C; 0.166667 h;
参考文献
Zhao, Gui-Ling; Lin, Shuangzheng; Korotvicka, Ales; Deiana, Luca; Kullberg, Martin; Cordova, Armando
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 13 p. 2291 - 2298