(1S)-3-[3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-外-8-氮杂双环[3.2.1]辛-8-基]-1-苯基-1-丙胺合成路线 (共 3 条)
反应条件
sodium carbonate in dichloromethane; water T=0 - 20°C;
参考文献
Zhao, Gui-Ling; Lin, Shuangzheng; Korotvicka, Ales; Deiana, Luca; Kullberg, Martin; Cordova, Armando
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 13 p. 2291 - 2298
反应条件
polimer bound carbodiimide in dichloromethane T=20°C; 1 h;
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
反应条件
Multi-step reaction with 4 steps 1: 90 percent / aq. NaHCO3 2: 75 percent / diisobutylaluminium hydride / CH2Cl2 / -78 °C3: 75 percent / Na(AcO)3BH / CH2Cl2 4: 95 percent / CF3CO2H / CH2Cl2
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007