acetic acid in methanol
T=20°C; modified Henry reaction; 2.5 h; Inert atmosphere;
参考文献
Greger, Jessica G.; Yoon-Miller, Sarah J. P.; Bechtold, Nathan R.; Flewelling, Scott A.; MacDonald, Jacob P.; Downey, Catherine R.; Cohen, Eric A.; Pelkey, Erin T.
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8203 - 8214
1: sodium hydroxide / methanol / 1 h / 5 °C / Inert atmosphere
2: pyridine; bromine / cyclohexane / Inert atmosphere; Reflux
3: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 20 °C / Inert atmosphere; Reflux
View Scheme
参考文献
Greger, Jessica G.; Yoon-Miller, Sarah J. P.; Bechtold, Nathan R.; Flewelling, Scott A.; MacDonald, Jacob P.; Downey, Catherine R.; Cohen, Eric A.; Pelkey, Erin T.
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8203 - 8214
Greger, Jessica G.; Yoon-Miller, Sarah J. P.; Bechtold, Nathan R.; Flewelling, Scott A.; MacDonald, Jacob P.; Downey, Catherine R.; Cohen, Eric A.; Pelkey, Erin T.
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8203 - 8214
1: urea; sodium nitrite / N,N-dimethyl-formamide / -10 °C / Inert atmosphere
2: acetic acid / methanol / 2.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Greger, Jessica G.; Yoon-Miller, Sarah J. P.; Bechtold, Nathan R.; Flewelling, Scott A.; MacDonald, Jacob P.; Downey, Catherine R.; Cohen, Eric A.; Pelkey, Erin T.
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8203 - 8214
1: phosphorus tribromide / dichloromethane / 1.08 h / 0 - 20 °C / Inert atmosphere
2: urea; sodium nitrite / N,N-dimethyl-formamide / -10 °C / Inert atmosphere
3: acetic acid / methanol / 2.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Greger, Jessica G.; Yoon-Miller, Sarah J. P.; Bechtold, Nathan R.; Flewelling, Scott A.; MacDonald, Jacob P.; Downey, Catherine R.; Cohen, Eric A.; Pelkey, Erin T.
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8203 - 8214
