2,4-二羟基-6-甲基吡啶合成路线 （共 34 条）
参考文献
Collie; Myers
Journal of the Chemical Society, 1892 , vol. 61, p. 726
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Sedgwick; Collie
Journal of the Chemical Society, 1895 , vol. 67, p. 408
参考文献
Collie; Myers
Journal of the Chemical Society, 1892 , vol. 61, p. 726
反应条件
1: phosphorus oxychloride / 120 °C 2: diluted potassium permanganate solution View Scheme
参考文献
Sedgwick; Collie
Journal of the Chemical Society, 1895 , vol. 67, p. 408
反应条件
phosphorus oxytribromide in DMF (N,N-dimethyl-formamide) T=110°C; 0.5 h;
参考文献
SPEEDEL EXPERIMENTA AG
Patent: WO2005/90304 A1, 2005 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 72 percent / conc. HNO3; NaNO2 / acetic acid / 0.5 h / 20 °C 2: 64 percent / POCl3; Et3N / 1 h / Heating View Scheme
参考文献
Stadlbauer; Fiala; Fischer; Hojas
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 5 p. 1253 - 1256
反应条件
1: 77 percent / 1.) reflux, 72 h, 2.) r.t., 12 h 2: 85 percent / H2 / Pd-C / acetic acid / Ambient temperature View Scheme
参考文献
Nguyen Chi Hung; Bisagni, Emile
Synthesis, 1984 , # 9 p. 765 - 766
反应条件
1: phosphorus oxychloride / 120 °C 2: bei der Zinkstaub-Destillation View Scheme
参考文献
Collie; Myers
Journal of the Chemical Society, 1892 , vol. 61, p. 726
参考文献
The Dupont Merck Pharmaceutical Company
Patent: US5583147 A1, 1996 ;
反应条件
1: 2,4-dihydroxy-6-methylpyridine With phosphorus oxytribromide in N,N-dimethyl-formamide T=110°C; 1 h; 2: With water in N,N-dimethyl-formamide T=20 - 25°C; 3: sodium difluoromonochloroacetate
参考文献
AstraZeneca AB
Patent: US2010/125087 A1, 2010 ;
Location in patent: Page/Page column 18 ;
US 20100125087 A1
反应条件
1: 95 percent / diphenyl ether / Heating
2: 80 percent / sodium hydroxide / ethane-1,2-diol; H2O / 2 h / Heating
View Scheme
参考文献
El-Essawy, Farag A.; Khattab, Ahmed F.; Zahran, Magdy A.; Gomaa, Sherif H.
Synthetic Communications, 2007 , vol. 37, # 18 p. 3225 - 3237
