(R)-1-(4-氟苯基)乙胺合成路线 （共 10 条）
反应条件
1: With C9H16BNO in tetrahydrofuran T=20°C; 24 h; 2: With borane-THF in tetrahydrofuran 24 h; Reflux; optical yield given as percent eeenantioselective reactionFurther stages;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 9 p. 716 - 721
反应条件
1: With (Ph)2SiH2; silver trifluoromethanesulfonate in tetrahydrofuran T=20°C; 25 h; 2: With hydrogenchloride in tetrahydrofuran; methanol Further stages. Title compound not separated from byproducts.;
参考文献
Chemical Communications, , # 22 p. 2360 - 2361
反应条件
Ni T=110°C; 2 h; Inert atmosphere;
参考文献
European Journal of Inorganic Chemistry, , # 14 p. 2623 - 2628
反应条件
1: With (SP)-O-ethylphenylphosphonothioic acid in diethyl ether T=20°C; 6 h; 2: With potassium hydroxide
参考文献
Organic Letters, , vol. 6, # 23 p. 4227 - 4230
反应条件
1: With ammonium acetate; sodium cyanoborohydride in methanol T=20°C; reductive amination; 2: racemate resolution; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 7 p. 1339 - 1347
反应条件
water in dimethyl sulfoxide T=30°C; pH=7; 18 h; aq. phosphate bufferMicrobiological reactionEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Canadian Journal of Chemistry, , vol. 90, # 1 p. 39 - 45
反应条件
(R)-alanine; Mycobacterium vanbaalenii (R)-selective ω-transaminase in water T=37°C; pH=7.5; Enzymatic reaction; Reagent/catalyst; enantioselective reaction;
参考文献
Chemical Communications, , vol. 49, # 77 p. 8629 - 8631
反应条件
1: Polaromonas sp. JS666 (S)-selective ω-transaminase; [14C]-2-Ketoglutaric acid; tris(hydroxymethyl)methylamine hydrochloride / water / 37 °C / pH 7.5 / |Enzymatic reaction 2: Mycobacterium vanbaalenii (R)-selective ω-transaminase; (R)-alanine / water / 37 °C / pH 7.5 / |Enzymatic reaction View Scheme
参考文献
Chemical Communications, , vol. 49, # 77 p. 8629 - 8631
反应条件
(S)-selective ω-transaminase from Ochrobactrum anthropi; L-threonine deaminase from Escherichia coli; pyridoxal 5'-phosphate T=37°C; pH=7.5; 3.5 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Green Chemistry, , vol. 14, # 8 p. 2137 - 2140
反应条件
sodium hydrogencarbonate in dichloromethane
3 h;
参考文献
Manjula; Malleshappa Noolvi; Vipan Parihar; Manohara Reddy; Ramani, Vijay; Gadad, Andanappa K.; Singh, Gurdial; Gopalan Kutty; Mallikarjuna Rao
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2923 - 2929
