7-BOC-2-噁-7-氮杂螺[4,5]-1-癸酮合成路线 （共 3 条）
反应条件
1: With oxygen; ozone in methanol; dichloromethane
T=-78°C; 1.58333 h;
2: With sodium tetrahydroborate in methanol; dichloromethane
T=-78 - 0°C; 2 h;
参考文献
Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John
Patent: US2003/236250 A1, 2003 ;
Location in patent: Page 35 ;
反应条件
1.1: hexane; diethyl ether; methanol / 4 h / 20 °C
2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere
2.2: 5 h / -78 °C
3.1: ozone; oxygen / dichloromethane; methanol / 2.17 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 °C / Cooling with ice-water bath
3.3: 20 °C / Cooling
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John
Patent: WO2011/141728 A1, 2011 ;
WO 2011/141728 A1
反应条件
1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere
1.2: 5 h / -78 °C
2.1: ozone; oxygen / dichloromethane; methanol / 2.17 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 °C / Cooling with ice-water bath
2.3: 20 °C / Cooling
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John
Patent: WO2011/141728 A1, 2011 ;
WO 2011/141728 A1
