2,4-二氯-5-氯磺酰基苯甲酸合成路线 （共 6 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Hrast, Martina; Turk, Samo; Sosic, Izidor; Knez, Damijan; Randall, Christopher P.; Barreteau, Helene; Contreras-Martel, Carlos; Dessen, Andrea; O'Neill, Alex J.; Mengin-Lecreulx, Dominique; Blanot, Didier; Gobec, Stanislav
European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 32 - 45
参考文献
Loev,B. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 956 - 965
反应条件
chlorosulfonic acid
T=0 - 140°C; 16 h;
参考文献
Hrast, Martina; Turk, Samo; Sosic, Izidor; Knez, Damijan; Randall, Christopher P.; Barreteau, Helene; Contreras-Martel, Carlos; Dessen, Andrea; O'Neill, Alex J.; Mengin-Lecreulx, Dominique; Blanot, Didier; Gobec, Stanislav
European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 32 - 45
参考文献
ASTRAZENECA; NPS PHARMACEUTICALS, INC.
Patent: WO2004/92135 A2, 2004 ;
Location in patent: Page 30-31 ;
WO 2004/092135 A2
反应条件
1: aq. NH3
2: HCl
View Scheme
参考文献
Loev,B. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 956 - 965
反应条件
1: in benzene
T=20°C; 2 h; Acidic aqueous solution;
2: 0.0166667 h;
参考文献
ASTRAZENECA; NPS PHARMACEUTICALS, INC.
Patent: WO2004/92135 A2, 2004 ;
Location in patent: Page 31 ;
WO 2004/092135 A2
