2-氧-3-哌啶羧酸乙酯合成路线 （共 12 条）
反应条件
1: 1. diazotation 2. hydrolyse 3. coupling and decarboxylation
2: 44 percent / P2O5 + 85percentH3PO4 / 65 - 110 °C
View Scheme
参考文献
Suvorov, N.N.; Vinograd, L.Kh.; Turchin, K.F.; Ill'ina, G.N.; Vigdorchik, M.M.; Filipenko, T.Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 8 p. 890 - 897
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , # 8 p. 1093 - 1100
反应条件
1: 1.) aq. KOH, 2.) aq. CH3COOH / 1.) RT, overnight, 2.) 0 deg C, 4 h
2: 90percent aq. HCOOH / 1 h / Heating
3: KOH / ethanol / 6 h / Heating
View Scheme
参考文献
Guengoer, Timur; Malabre, Patrice; Teulon, Jean-Marie; Camborde, Francoise; Meignen, Joelle; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4307 - 4316
