2-氧-3-哌啶羧酸乙酯合成路线 （共 12 条）
反应条件
hydrogen; nickel in ethanol T=20°C; P=3800.26 Torr; 72 h;
参考文献
Michael, Joseph P.; De Koning, Charles B.; Van der Westhuyzen, Christiaan W.; Fernandes, Manuel A.
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 17 p. 2055 - 2062
反应条件
nickel T=100°C; P=102971 Torr; Hydrogenation;
参考文献
Albertson; Fillman
Journal of the American Chemical Society, 1949 , vol. 71, p. 2818
反应条件
1: sodium ethylate / 65 °C / als Hauptprodukt 2: Raney nickel / 100 °C / 102971 Torr / Hydrogenation View Scheme
参考文献
Michael, Joseph P.; De Koning, Charles B.; Van der Westhuyzen, Christiaan W.; Fernandes, Manuel A.
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 17 p. 2055 - 2062
反应条件
potassium hydroxide T=30°C;
参考文献
Soti; Incze; Kardos-Balogh; Kajtar-Peredy; Szantay
Synthetic Communications, 1993 , vol. 23, # 12 p. 1689 - 1698
反应条件
1: 1.) aq. KOH, 2.) aq. CH3COOH / 1.) RT, overnight, 2.) 0 deg C, 4 h 2: 87 percent / 90percent aq. HCOOH / 1 h / Heating View Scheme
参考文献
Abramovitch
Journal of the Chemical Society, 1956 , p. 4593,4597
反应条件
1: KOH 2: HCOOH / H2O / 3 h / Heating 3: triethyloxonium tetrafluoroborate View Scheme
参考文献
Decker, Michael
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 3 p. 305 - 313
反应条件
1: 36 percent / P2S5 / toluene / Ambient temperature 2: tetrahydrofuran 3: 25 percent / NaBH4 / methanol / 2 h View Scheme
参考文献
Sundberg, Richard J.; Walters, Claudia Powers; Bloom, Jonathan D.
Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3730 - 3732
反应条件
1: KOH
2: HCOOH / H2O / 3 h / Heating
View Scheme
参考文献
Guengoer, Timur; Malabre, Patrice; Teulon, Jean-Marie; Camborde, Francoise; Meignen, Joelle; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4307 - 4316
反应条件
n-butyllithium in tetrahydrofuran
T=-78 - 60°C;
参考文献
Oguri, Hiroki; Schreiber, Stuart L.
Organic Letters, 2005 , vol. 7, # 1 p. 47 - 50
反应条件
1. diazotation 2.hydolyse 3.coupling and decarboxylation; Multistep reaction;
参考文献
Suvorov, N.N.; Vinograd, L.Kh.; Turchin, K.F.; Ill'ina, G.N.; Vigdorchik, M.M.; Filipenko, T.Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 8 p. 890 - 897
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , # 8 p. 1093 - 1100
