2-[2-(2-氟乙氧基)乙氧基]乙醇合成路线 （共 7 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
2 h; Heating;
参考文献
Qu, Wenchao; Kung, Mei-Ping; Hou, Catherine; Benedum, Tyler E.; Kung, Hank F.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2157 - 2165
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
1 h; RefluxInert atmosphere;
参考文献
SIEMENS MEDICAL SOLUTIONS USA, INC.
Patent: WO2009/102498 A1, 2009 ;
Location in patent: Page/Page column 96-97 ;
反应条件
1: 66 percent / Ag2O; KI / CH2Cl2 / 0.33 h / -5 °C
2: 95 percent / TBAF / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Qu, Wenchao; Kung, Mei-Ping; Hou, Catherine; Benedum, Tyler E.; Kung, Hank F.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2157 - 2165
反应条件
5 Pd(II)/C(eggshell); hydrogen; palladium(II) oxide hydrate in tetrahydrofuran
2 h; Inert atmosphere;
参考文献
Van Oosten, Erik M.; Wilson, Alan A.; Mamo, David C.; Pollock, Bruce G.; Mulsant, Benoit H.; Houle, Sylvain; Vasdev, Neil
Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1222 - 1232
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 160 °C / Inert atmosphere; Microwave irradiation
3: 5 Pd(II)/C(eggshell); hydrogen; palladium(II) oxide hydrate / tetrahydrofuran / 2 h / Inert atmosphere
View Scheme
参考文献
Van Oosten, Erik M.; Wilson, Alan A.; Mamo, David C.; Pollock, Bruce G.; Mulsant, Benoit H.; Houle, Sylvain; Vasdev, Neil
Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1222 - 1232
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 160 °C / Inert atmosphere; Microwave irradiation
2: 5 Pd(II)/C(eggshell); hydrogen; palladium(II) oxide hydrate / tetrahydrofuran / 2 h / Inert atmosphere
View Scheme
参考文献
Van Oosten, Erik M.; Wilson, Alan A.; Mamo, David C.; Pollock, Bruce G.; Mulsant, Benoit H.; Houle, Sylvain; Vasdev, Neil
Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1222 - 1232
反应条件
sodium sulfate
T=130°C;
参考文献
Buckle; Saunders
Journal of the Chemical Society, 1949 , p. 2777
