(氯亚甲基)二甲基氯化铵合成路线 （共 84 条）
反应条件
1: T=100°C; Vilsmeier-Haack reaction; 1 h; Inert atmosphere; 2: With water T=50°C; 2 h;
参考文献
Lopez, Sergio; McCabe, Thomas; Stanley McElhinney; McMurry, T. Brian H.; Rozas, Isabel
Tetrahedron Letters, 2009 , vol. 50, # 44 p. 6022 - 6024
反应条件
(i) CHCl3, (ii) aq. K2CO3; Multistep reaction;
参考文献
Ciernik,J.
Collection of Czechoslovak Chemical Communications, 1972 , vol. 37, p. 2273 - 2281
反应条件
1: in N,N-dimethyl-formamide T=20°C; 16 h; 2: With sodium hydroxide in water; N,N-dimethyl-formamide T=0°C; pH=7;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/130231 A1, 2009 ;
Location in patent: Page/Page column 60 ;
WO 2009/130231 A1
反应条件
(i) CHCl3, (ii) aq. K2CO3; Multistep reaction;
参考文献
Ciernik,J.
Collection of Czechoslovak Chemical Communications, 1972 , vol. 37, p. 2273 - 2281
反应条件
T=150°C; 0.833333 h; Ionic liquidInert atmosphereMicrowave irradiation;
参考文献
Tseng, Ming-Chung; Cheng, Hui-Ting; Shen, Meng-Jane; Chu, Yen-Ho
Organic Letters, 2011 , vol. 13, # 16 p. 4434 - 4437
反应条件
in N,N-dimethyl-formamide T=150°C; 0.833333 h; Inert atmosphereMicrowave irradiation;
参考文献
Tseng, Ming-Chung; Cheng, Hui-Ting; Shen, Meng-Jane; Chu, Yen-Ho
Organic Letters, 2011 , vol. 13, # 16 p. 4434 - 4437
反应条件
in toluene 1.) RT, 2.) reflux;
参考文献
Stanovnik, Branko; Bajt, OLiver; Balcic, Branko; Koren, Bozidar; Prhavc, Marija; et al.
Heterocycles, 1984 , vol. 22, # 7 p. 1545 - 1554
反应条件
CH3COONa/CH3COOH-buffer in 1,4-dioxane refluxing of mixt. (8h), cooling to room temp., addn. of CH3COONa/CH3COOH, further reflux (2h); cooling, pouring onto H2O, extn. (CHCl3), washing of organic layer (aq. NaHCO3), drying (MgSO4), evapn. (vacuo), distn.;
参考文献
Bryce, Martin R.; Fakley, Martin E.
Synthetic Communications, 1988 , vol. 18, # 2 p. 181 - 184
反应条件
sodium acetate; acetic acid 2.) 1,4-dioxane, reflux, 8 h, 3.) reflux, 2 h; Yield given. Multistep reaction;
参考文献
Bryce, Martin R.; Fakley, Martin E.
Synthetic Communications, 1988 , vol. 18, # 2 p. 181 - 184
反应条件
Yield given. Multistep reaction;
参考文献
Brehme, Rainer; Nikolajewski, Hans-Edmund
Tetrahedron Letters, 1982 , vol. 23, # 11 p. 1131 - 1134
