bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; 1 h;

bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; 2 h;

1.1: LiHMDS / tetrahydrofuran / -78 °C 1.2: lithium tert-butyl peroxide / tetrahydrofuran; toluene / 2.5 h / -78 - 0 °C 1.3: 80 percent / tetrahydrofuran; toluene / -78 - 0 °C 2.1: 88 percent / trifluoromethanesulfonimide / CH2Cl2 / 1 h / 20 °C View Scheme

1.1: BuLi / tetrahydrofuran; hexane / 1.5 h / 20 °C 1.2: MgBr2 / tetrahydrofuran; hexane / 0.5 h / 20 °C 1.3: tetrahydrofuran; hexane / 3 h / 20 °C 2.1: NaOH / methanol; tetrahydrofuran; H2O 3.1: LiHMDS / tetrahydrofuran / -78 °C 3.2: lithium tert-butyl peroxide / tetrahydrofuran; toluene / 2.5 h / -78 - 0 °C 3.3: 80 percent / tetrahydrofuran; toluene / 0.5 h / 0 °C 4.1: 74 percent / HNTf2 / CH2Cl2 / 1 h / 20 °C View Scheme

1.1: LiHMDS / tetrahydrofuran / -78 °C 1.2: lithium tert-butyl peroxide / tetrahydrofuran; toluene / 2.5 h / -78 - 0 °C 1.3: 99 percent / tetrahydrofuran; toluene / 0.5 h / 0 °C 2.1: 88 percent / HNTf2 / CH2Cl2 / 2 h / 20 °C View Scheme

1: With piperazine microwave irradiation; 2: With sulfuric acid; acetic acid microwave irradiation; Further stages.;

pyrrolidine; propionic acid T=45°C; Aldol-Robinson cascade reaction; 24 h;

tri-i-propoxy lanthanium T=50°C; 2 h;

Yield given. Multistep reaction;

diethylamine Behandeln der Reaktionsprodukte mit Kalilauge;