3,5-二氟苯胺合成路线

372-39-43,5-二氟苯胺

3743-91-7N-(4-乙酰氨基-2,6-二氟苯基)乙酰胺

参考文献

Miller et al.
Cancer Research, 1957 , vol. 17, p. 387,388

372-39-43,5-二氟苯胺+

68-12-2N,N-二甲基甲酰胺

777089-82-44-氨基-2,6-二氟苯甲醛

参考文献

PHARMACIA and UPJOHN COMPANY
Patent: WO2004/89943 A1, 2004 ;
Location in patent: Page 141 ;

372-39-43,5-二氟苯胺

791594-33-7

参考文献

Bayer Pharmaceuticals Corporation
Patent: US2004/224997 A1, 2004 ;
Location in patent: Page 31 ;

372-39-43,5-二氟苯胺

99389-26-13,5-二氟苯硫酚

参考文献

Kim, Dae-Kee; Gam, Jongsik; Kim, Young-Woo; Lim, Jinsoo; Kim, Hun-Taek; Kim, Key H.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2363 - 2373

372-39-43,5-二氟苯胺

420787-26-4

参考文献

Lovell, Peter J.; Blaney, Frank E.; Goodacre, Caroline J.; Scott, Claire M.; Smith, Paul W.; Starr, Kathryn R.; Thewlis, Kevin M.; Vong, Antonio K.K.; Ward, Simon E.; Watson, Jeannette M.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1033 - 1036

372-39-43,5-二氟苯胺+

75-36-5乙酰氯

458-11-73’,4’-二氟乙酰苯胺

参考文献

GEORGIA TECH RESEARCH CORPORATION
Patent: WO2005/123737 A2, 2005 ;
Location in patent: Page/Page column 120 ;

64-18-6甲酸+

372-39-43,5-二氟苯胺

470458-51-63,5-二氟-N-甲基苯胺

参考文献

Herzon, Seth B.; Hartwig, John F.
Journal of the American Chemical Society, 2007 , vol. 129, # 21 p. 6690 - 6691

372-39-43,5-二氟苯胺

470458-51-63,5-二氟-N-甲基苯胺

参考文献

Zhang, Shu Lan; Zhai, Xin; Zhang, Shi Jiao; Yu, Hong Hao; Gong, Ping
Chinese Chemical Letters, 2010 , vol. 21, # 8 p. 939 - 942

372-39-43,5-二氟苯胺+

108-23-6氯甲酸异丙酯

570390-90-8

参考文献

PHARMACIA and UPJOHN COMPANY
Patent: WO2004/89943 A1, 2004 ;
Location in patent: Page 72-73 ;

372-39-43,5-二氟苯胺

379228-57-62-氨基-4,6-二氟苯甲酸甲酯

参考文献

Ford, J. Gair; Pointon, Simon M.; Powell, Lyn; Siedlecki, Paul S.; Baum, John; Chubb, Richard; Fieldhouse, Robin; Muxworthy, James; Nivlet, Alex; Stenson, Rachel; Warwick, Eleanor
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1078 - 1087