3-氨基-4,4,4-三氟巴豆酸乙酯合成路线 （共 11 条）
反应条件
1: With sodium ethanolate 2: With ammonium acetate; acetic acid in cyclohexane 5 h; Heating / reflux;
参考文献
DEGUSSA AG
Patent: WO2004/16579 A1, 2004 ;
Location in patent: Page 9; 10 ;
参考文献
Lutz,A.W.; Trotto,S.H.
Journal of Heterocyclic Chemistry, 1972 , vol. 9, p. 513 - 522
反应条件
1: 55 percent / chlorobenzene / 2 h / 135 °C 2: 92 percent / POCl3 / Heating 3: 31 percent / NaBH4 / dimethylformamide / 0.33 h / 0 °C / exothermic reaction View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
in chlorobenzene T=135°C; 2 h;
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
in chlorobenzene 1.) 70 deg C, 17 h, 2.) 80 deg C, 2 h, 3.) 90 deg C, 2 h;; Yields of byproduct given;
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
1: 55 percent / chlorobenzene / 2 h / 135 °C 2: 92 percent / POCl3 / Heating View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
sodium methylate in dimethyl sulfoxide T=0 - 20°C; 15 h; Molecular sieve;
参考文献
Sidduri, Achyutharao; Tilley, Jefferson W.; Lou, Jianping; Tare, Nadine; Cavallo, Gary; Frank, Karl; Pamidimukkala, Anjula; Choi, Duk Soon; Gerber, Louise; Railkar, Aruna; Renzetti, Louis
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 1026 - 1031
参考文献
Hebeisen, Paul; Panousis, Constantinos G.; Roever, Stephan; Waldmeier, Pius; Wright, Matthew
Patent: US2009/247588 A1, 2009 ;
Location in patent: Page/Page column 10 ;
反应条件
in chlorobenzene
1.) 70 deg C, 17 h, 2.) 80 deg C, 2 h, 3.) 90 deg C, 2 h;; Yields of byproduct given;
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
反应条件
1: chlorobenzene / 1.) 70 deg C, 17 h, 2.) 80 deg C, 2 h, 3.) 90 deg C, 2 h;
2: 57 percent / triethylamine / exothermic reaction
View Scheme
参考文献
Lee, Len F.; Schleppnik, Francis M.; Howe, Robert K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1621 - 1630
