3-氨基-呋喃并[2,3-B]嘧啶-2-甲酸乙酯合成路线 (共 7 条)
反应条件
copper(l) iodide; caesium carbonate T=70°C; 4 h;
参考文献
US2010/261714 A1, ;
Page/Page column 75 ;
反应条件
1: aq. NaOH / ethanol 2: SOCl2 / Heating 3: aq. NH3 / tetrahydrofuran 4: aq. NaOH / propan-2-ol / Heating 5: HBr / acetic acid / Heating 6: AcONa / Heating 7: phosphorus oxychloride / Heating 8: Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 9 p. 2438 - 2442
反应条件
1: in dichloromethane T=0 - 20°C; Inert atmosphere; 2: With water in dichloromethane T=70°C; 0.166667 h; 3: With sodium hydroxide in water 1 h;
参考文献
KARUS THERAPEUTICS LIMITED; SHUTTLEWORTH, Stephen Joseph; CECIL, Alexander Richard Liam; HILL, Thomas James; SILVA, Franck Alexandre
Patent: WO2011/21038 A1, 2011 ;
Location in patent: Page/Page column 19; 24-25 ;
WO 2011/021038 A1
反应条件
1: aq. NaOH / ethanol
2: SOCl2 / Heating
3: aq. NH3 / tetrahydrofuran
4: aq. NaOH / propan-2-ol / Heating
View Scheme
参考文献
Hayakawa, Masahiko; Kaizawa, Hiroyuki; Moritomo, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Yamano, Mayumi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-ichi; Raynaud, Florence I.; Workman, Paul; Waterfield, Michael D.; Parker, Peter
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2438 - 2442
反应条件
1: aq. NaOH / ethanol
2: SOCl2 / Heating
3: aq. NH3 / tetrahydrofuran
4: aq. NaOH / propan-2-ol / Heating
5: HBr / acetic acid / Heating
6: AcONa / Heating
View Scheme
参考文献
Hayakawa, Masahiko; Kaizawa, Hiroyuki; Moritomo, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Yamano, Mayumi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-ichi; Raynaud, Florence I.; Workman, Paul; Waterfield, Michael D.; Parker, Peter
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2438 - 2442
参考文献
Hayakawa, Masahiko; Kaizawa, Hiroyuki; Moritomo, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Yamano, Mayumi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-ichi; Raynaud, Florence I.; Workman, Paul; Waterfield, Michael D.; Parker, Peter
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2438 - 2442
反应条件
1: aq. NaOH / ethanol
2: SOCl2 / Heating
3: aq. NH3 / tetrahydrofuran
View Scheme
参考文献
Hayakawa, Masahiko; Kaizawa, Hiroyuki; Moritomo, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Yamano, Mayumi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-ichi; Raynaud, Florence I.; Workman, Paul; Waterfield, Michael D.; Parker, Peter
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2438 - 2442