1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸合成路线 （共 22 条）
反应条件
1: 2-hydroxy 5-pyridine carboxylic acid With sodium hydride in methanol T=20 - 60°C; 0.583333 h; Inert atmosphere; 2: methyl iodide in methanol T=60°C; 3: With hydrogenchloride; sodium hydroxide in methanol; water T=60°C;
参考文献
ALMIRALL, S.A.; GRIMA POVEDA, Pedro Manuel; AGUILAR IZQUIERDO, Nuria; MIR CEPEDA, Marta; LOPEZ MARTINEZ, Manuel
Patent: WO2010/43377 A1, 2010 ;
Location in patent: Page/Page column 66 ;
WO 2010/043377 A1
反应条件
1: 2-hydroxy 5-pyridine carboxylic acid With sodium hydride in methanol T=62°C; 2: methyl iodide in methanol
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259862 A1, 2007 ;
Location in patent: Page/Page column 29 ;
US 20070259862 A1
反应条件
potassium hydroxide 4 h; Heating;
参考文献
Buurman; Van der Plas
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 4 p. 1015 - 1018
反应条件
sodium hydroxide; potassium hexacyanoferrate(III)
参考文献
Weber, Horst; Lippe, Gotelind von der
Chemische Berichte, 1985 , vol. 118, # 9 p. 4086 - 4098
反应条件
1: 75 percent / potassium permanganate, NH3(l) / 4 h / -33 °C 2: 90 percent / aq. KOH / 4 h / Heating View Scheme
参考文献
Buurman; Van der Plas
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 4 p. 1015 - 1018
反应条件
potassium hydroxide durch Eindampfen und Erhitzen des Produkts mit Methyljodid und Methanol auf 100grad bis 110grad;
参考文献
v. Pechmann; Welsh
Chemische Berichte, 1884 , vol. 17, p. 2394
参考文献
Sugasawa; Kirisawa
Pharmaceutical Bulletin, 1955 , vol. 3, p. 190,192
反应条件
potassium chloride in water T=25°C; Rate constant;
参考文献
Deady, Leslie W.
Australian Journal of Chemistry, 1985 , vol. 38, # 4 p. 637 - 641
反应条件
1: anschliessendes Behandeln mit K3<Fe(CN)6> 2: water; hydrochloric acid 3: aqueous NaOBr View Scheme
参考文献
Sugasawa; Kirisawa
Pharmaceutical Bulletin, 1955 , vol. 3, p. 190,192
反应条件
1: water; hydrochloric acid 2: aqueous NaOBr View Scheme
参考文献
Sugasawa; Kirisawa
Pharmaceutical Bulletin, 1955 , vol. 3, p. 190,192
