反应条件
1.1: chloramine-T / water; tert-butyl alcohol / 20 °C
1.2: 20 °C
2.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere
3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
4.1: triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere
6.1: 5 Pd(II)/C(eggshell); hydrogen / ethyl acetate / 3 h / 20 °C
View Scheme
参考文献
Yermolina, Maria V.; Wang, Jizhen; Caffrey, Michael; Rong, Lijun L.; Wardrop, Duncan J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 3 p. 765 - 781
