4-(5-氨基-6-苄基吡嗪-2-基)苯酚合成路线 （共 22 条）
反应条件
1: With hydrazine hydrate in ethylene glycol
T=100°C; Wolff-Kishner reduction; 1 h;
2: With potassium hydroxide
T=240°C;
参考文献
Mosrin, Marc; Bresser, Tomke; Knochel, Paul
Organic Letters, 2009 , vol. 11, # 15 p. 3406 - 3409
反应条件
hydrogenchloride in ethanol; water
参考文献
Klaubert, Dieter H.; Meisenheimer, Poncho; Unch, James
Patent: US2012/117667 A1, 2012 ;
反应条件
1: 88 percent / (PhCN)2PdCl2; 1,4-bis(diphenylphosphino)butane; Na2CO3 / toluene; ethanol; H2O / 4 h / Heating
2: 75 percent / pyridine hydrochloride / 0.5 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Organic Preparations and Procedures International, 2001 , vol. 33, # 5 p. 477 - 485
反应条件
1: 89 percent / tetra-n-butylammonium tribromide; pyridine / CHCl3 / 0.75 h / 20 °C
2: 88 percent / (PhCN)2PdCl2; 1,4-bis(diphenylphosphino)butane; Na2CO3 / toluene; ethanol; H2O / 4 h / Heating
3: 75 percent / pyridine hydrochloride / 0.5 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Organic Preparations and Procedures International, 2001 , vol. 33, # 5 p. 477 - 485
反应条件
in methanol
T=0°C; Rearrangement; 0.416667 h; Photolysis;
参考文献
Zheng, Jing Ling; Chen, Feng Qi; Hirano, Takashi; Ohmiya, Yoshihiro; Maki, Shojiro; Niwa, Haruki; Ohashi, Mamoru
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 2 p. 465 - 469
反应条件
1.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / hexane / 0.5 h / 0 - 60 °C
1.2: 0.5 h / 0 °C
2.1: pyridine; tetra-n-butylammonium tribromide / chloroform / 1 h / 20 °C
3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene; ethanol / Inert atmosphere; Reflux
4.1: pyridine hydrochloride / 120 - 190 °C / Inert atmosphere
View Scheme
参考文献
UNIVERSITA DEGLI STUDI DI SIENA; GIULIANI, Germano; CAPPELLI, Andrea; VOMERO, Salvatore; ANZINI, Maurizio
Patent: WO2011/7314 A1, 2011 ;
反应条件
1: 94 percent / pyridine; TiCl4 / 0.5 h / 20 °C
2: 95 percent / Zn; AcOH / CH2Cl2; methanol / 0.33 h / Heating
View Scheme
参考文献
Kakoi, Hisae
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 2 p. 301 - 302
反应条件
1: 94 percent / pyridine; TiCl4 / 0.5 h / 20 °C
2: 95 percent / Zn; AcOH / CH2Cl2; methanol / 0.33 h / Heating
View Scheme
参考文献
Kakoi, Hisae
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 2 p. 301 - 302
反应条件
1: pyridine, TiCl4
2: H2 / Raney-Ni
3: pyridinium chloride
View Scheme
参考文献
Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi; Ohashi, Mamoru; Ohmiya, Yoshihiro; Tsuji, Frederick I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1607 - 1612
反应条件
1: pyridine, TiCl4
2: H2 / Raney-Ni
3: pyridinium chloride
View Scheme
参考文献
Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi; Ohashi, Mamoru; Ohmiya, Yoshihiro; Tsuji, Frederick I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1607 - 1612
