3-甲基-2-氧代丁酸钠合成路线 （共 15 条）
反应条件
lithium hydroxide; water in tetrahydrofuran T=20°C;
参考文献
MERCK and CO., INC.
Patent: WO2005/118529 A2, 2005 ;
Location in patent: Page/Page column 26 ;
反应条件
sodium hydroxide 1.) ether/CH2Cl2, -10 to 5 deg C, 2.) H2O, 5 deg C; Yield given. Multistep reaction;
参考文献
Fizet
Helvetica Chimica Acta, 1982 , vol. 65, # 7 p. 2024 - 2028
反应条件
thionyl chloride 0.5 h;
参考文献
Bendall, Justin G.; Cambie, Richard C.; Moratti, Stephen C.; Rutledge, Peter S.; Woodgate, Paul D.
Australian Journal of Chemistry, 1995 , vol. 48, # 10 p. 1747 - 1756
反应条件
15NH4Cl; nicotinamide adenine dinucleotide; recombinant glucose dehydrogenase from Bacillus subtilis; recombinant galactomutarotase from Escherichia coli in sodium hydroxide T=30°C; pH=8.0 - 8.2;
参考文献
Chiriac, Maria; Lupan, Iulia; Bucurenci; Popescu; Palibroda
Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 4 p. 171 - 174
反应条件
Zn(ClO4)2; (R)-15-amino-methyl-14-hydroxy-5,5-dimethyl-2,8-dithialt;9gt;(2,5)pyridinophane in methanol 24 h; Ambient temperature;
参考文献
Tachibana, Yoji; Ando, Makoto; Kuzuhara, Hiroyoshi
Chemistry Letters, 1982 , p. 1765 - 1768
反应条件
L-α-Me-isoleucine; copper(II) sulfate T=160°C; 2 h; optical yield given as percent ee;
参考文献
Levine, Mindy; Kenesky, Craig Scott; Mazori, Daniel; Breslow, Ronald
Organic Letters, 2008 , vol. 10, # 12 p. 2433 - 2436
反应条件
L-α-Me-isoleucine; copper(II) sulfate T=160°C; 2 h; optical yield given as percent ee;
参考文献
Levine, Mindy; Kenesky, Craig Scott; Mazori, Daniel; Breslow, Ronald
Organic Letters, 2008 , vol. 10, # 12 p. 2433 - 2436
反应条件
hydrogenchloride; water in tert-butyl methyl ether T=0°C; Product distribution / selectivity;
参考文献
MERCK and CO., INC.
Patent: WO2005/118529 A2, 2005 ;
Location in patent: Page/Page column 26-29 ;
反应条件
hydrogenchloride; potassium carbonate 1.) H2O, 38-40 deg C, (well controlled addition of formaldehyde); Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Fizet
Helvetica Chimica Acta, 1982 , vol. 65, # 7 p. 2024 - 2028
反应条件
hydrogenchloride; potassium carbonate 1.) H2O, 38-40 deg C, (well controlled addition of formaldehyde); Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Fizet
Helvetica Chimica Acta, 1982 , vol. 65, # 7 p. 2024 - 2028
