1,4-双(2-氯乙氧基)苯合成路线 （共 8 条）
反应条件
pyridine; thionyl chloride T=20°C;
参考文献
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010
反应条件
potassium carbonate in acetone 24 h; Heating;
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
反应条件
1: NaOH, sodium dithionite / butan-1-ol / 30 h / Heating 2: conc. HCl / methanol; CH2Cl2 / 4 h / Ambient temperature 3: SOCl2, pyridine / toluene / 24 h / Heating View Scheme
参考文献
Gibson, Harry W.; Nagvekar, Devdatt S.; Delaviz, Yadollah; Bryant, William S.
Canadian Journal of Chemistry, 1998 , vol. 76, # 10 p. 1429 - 1436
反应条件
potassium hydroxide; Aliquat 16 h;
参考文献
Sijbesma, R. P.; Nolte, R. J. M.
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 12 p. 643 - 647
反应条件
1: 91 percent / Br2; ZnCl2 / acetic acid 2: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating 3: AlCl3 / CH2Cl2 / 16 h 4: 92 percent / TFA; Et3SiH / 6 h / Heating 5: 64 percent / DDQ / dioxane / 24 h / Heating View Scheme
参考文献
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010
反应条件
1: 92 percent / Fe, Br2 / CCl4 / 4.5 h / Ambient temperature 2: 80 percent / n-BuLi / tetrahydrofuran; hexane / 0.17 h 3: 71 percent / SnCl4 / CH2Cl2 / 0.5 h View Scheme
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
反应条件
bromine; iron in tetrachloromethane 4.5 h; Ambient temperature;
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
反应条件
1: 91 percent / Br2; ZnCl2 / acetic acid
2: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
