4,4,4-三氟丁酸乙酯合成路线 （共 17 条）
反应条件
potassium hydroxide in methanol (electrochemical oxidation);
参考文献
Renaud,R.N.; Champagne,P.J.
Canadian Journal of Chemistry, 1975 , vol. 53, p. 529 - 534
反应条件
hydrogenchloride in dichloromethane
参考文献
Wyeth
Patent: US2004/198778 A1, 2004 ;
US 20040198778 A1
反应条件
hydrogenchloride; potassium hydroxide in methanol; water
参考文献
Sumitomo Chemical Company, Limited
Patent: US5653990 A1, 1997 ;
反应条件
lithium aluminium tetrahydride in diethyl ether 3 h; Heating;
参考文献
Ratier, Max; Pereyre, Michel; Davies, Alwyn G.; Sutcliffe, Roger
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , p. 1907 - 1916
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; dichloromethane
参考文献
Imperial Chemical Industries PLC
Patent: US5286740 A1, 1994 ;
反应条件
1: 1.) diisopropylamine, butyllithium / 1.) THF, hexanes, -70 deg C, 30 min, 2.) THF, hexanes, from -70 deg C to RT
2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 2.) THF, -30 deg C
View Scheme
参考文献
Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297
反应条件
sodium hydroxide; sulfuric acid in water; benzene
参考文献
G. D. Searle and Co.
Patent: US5144037 A1, 1992 ;
