2-(4-甲氧基苯基)-1-环己酮合成路线 （共 28 条）
反应条件
potassium phosphate; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; (Mor-DalPhos) in tert-butyl alcohol
T=110°C; Inert atmosphereGlovebox;
参考文献
Alsabeh, Pamela G.; Stradiotto, Mark
Angewandte Chemie - International Edition, 2013 , vol. 52, # 28 p. 7242 - 7246
Angew. Chem., 2013 , vol. 125, # 28 p. 7383 - 7387
反应条件
titanium tetrachloride in dichloromethane
0.5 h; Ambient temperature;
参考文献
Lee, Kilsung; Oh, Dong Young
Tetrahedron Letters, 1988 , vol. 29, # 24 p. 2977 - 2978
参考文献
Nachtsheim, Corina M.; Frahm, August W.
Archiv der Pharmazie (Weinheim, Germany), 1989 , vol. 322, p. 187 - 197
反应条件
1.1: t-BuLi / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 0.5 h / -78 °C
2.1: H2SO4; AcOH / 0.5 h / 0 °C
3.1: BH3 / tetrahydrofuran / 2 h / 0 - 25 °C
3.2: aq. H2O2; aq. NaOH / tetrahydrofuran
4.1: PCC / CH2Cl2 / 8 h / 25 °C
View Scheme
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
1.1: t-BuLi / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 0.5 h / -78 °C
2.1: H2SO4; AcOH / 0.5 h / 0 °C
3.1: BH3 / tetrahydrofuran / 2 h / 0 - 25 °C
3.2: aq. H2O2; aq. NaOH / tetrahydrofuran
4.1: PCC / CH2Cl2 / 8 h / 25 °C
View Scheme
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
1: CuBr*Me2S / tetrahydrofuran / 0 °C
2: aq. Dess-Martin periodinane / CH2Cl2 / 20 °C
View Scheme
参考文献
Pinard, Emmanuel; Ceccarelli, Simona M.; Stalder, Henri; Alberati, Daniela
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 349 - 353
反应条件
1: 1.) t-BuLi, 2.) BF3*Et2O / 1.) n-pentane, THF, -78 deg C, 30 min, 2.) n-pentane, THF, , -78 deg C, 15 min
2: 93 percent / pyridine, dicyclohexylcarbodiimide, TFA / dimethylsulfoxide; CH2Cl2
View Scheme
参考文献
Vaccaro, Wayne; Amore, Cindy; Berger, Joel; Burrier, Robert; Clader, John; Davis, Harry; Domalski, Martin; Fevig, Tom; Salisbury, Brian; Sher, Rosy
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1704 - 1719
反应条件
jones reagent in acetone
1 h;
参考文献
Collins, David J.; Molinski, Tadeusz F.; Sjoevall, Jan
Australian Journal of Chemistry, 1983 , vol. 36, # 2 p. 361 - 370
反应条件
pyridine in tetrahydrofuran
6 h; Ambient temperature;
参考文献
Pinhey, John T.; Rowe, Bruce A.
Australian Journal of Chemistry, 1983 , vol. 36, # 4 p. 789 - 794
反应条件
diethyl ether
T=-20°C; Erhitzen des Reaktionsgemisches mit Ameisensaeure;
参考文献
Goldschmidt; Veer
Recueil des Travaux Chimiques des Pays-Bas, 1948 , vol. 67, p. 489,506
