2-(4-甲氧基苯基)-1-环己酮合成路线 （共 28 条）
反应条件
potassium hydroxide in tetrahydrofuran; ethanol
参考文献
Balsamo,A. et al.
Tetrahedron, 1973 , vol. 29, p. 2183 - 2188
反应条件
anschliessend Behandeln mit wss.NH4Cl und Erhitzen des Reaktionsprodukts mit Acetanhydrid;
参考文献
Mueller; May
Journal of the American Chemical Society, 1949 , vol. 71, p. 3313,3316
反应条件
sodium t-butanolate; palladium diacetate; 2'-hydroxy-2-di-cyclohexylphosphinobiphenyl-4'-sulfonic acid in N,N-dimethyl-formamide
T=80°C; 20.25 h;
参考文献
Meudt, Andreas; Nerdinger, Sven; Lehnemann, Bernd Wilhelm; Vogel, Till; Snieckus, Victor
Patent: US2008/221350 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
tris-(dibenzylideneacetone)dipalladium(0); Bu3SnF; tri-tert-butyl phosphine in toluene
24 h; Inert atmosphereReflux;
参考文献
Cheon, Cheol Hong; Kanno, Osamu; Toste, F. Dean
Journal of the American Chemical Society, 2011 , vol. 133, # 34 p. 13248 - 13251
反应条件
Dess-Martin periodane in dichloromethane
T=0 - 20°C;
参考文献
Macleod, Fraser; Lang, Stuart; Murphy, John A.
Synlett, 2010 , # 4 art. no. D32209ST, p. 529 - 534
反应条件
tri-tert-butyl phosphine; tri-n-butyltin fluoride; tris(dibenzylideneacetone)dipalladium (0) in benzene
19 h; Heating;
参考文献
Iwama, Tetsuo; Rawal, Viresh H.
Organic Letters, 2006 , vol. 8, # 25 p. 5725 - 5728
反应条件
tri-tert-butyl phosphine; tri-n-butyltin fluoride; tris(dibenzylideneacetone)dipalladium (0) in benzene
20 h; Heating;
参考文献
Iwama, Tetsuo; Rawal, Viresh H.
Organic Letters, 2006 , vol. 8, # 25 p. 5725 - 5728
反应条件
pyridine; dicyclohexyl-carbodiimide; trifluoroacetic acid in dichloromethane; dimethyl sulfoxide
参考文献
Vaccaro, Wayne; Amore, Cindy; Berger, Joel; Burrier, Robert; Clader, John; Davis, Harry; Domalski, Martin; Fevig, Tom; Salisbury, Brian; Sher, Rosy
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1704 - 1719
反应条件
1.1: BH3 / tetrahydrofuran / 2 h / 0 - 25 °C
1.2: aq. H2O2; aq. NaOH / tetrahydrofuran
2.1: PCC / CH2Cl2 / 8 h / 25 °C
View Scheme
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
1.1: H2SO4; AcOH / 0.5 h / 0 °C
2.1: BH3 / tetrahydrofuran / 2 h / 0 - 25 °C
2.2: aq. H2O2; aq. NaOH / tetrahydrofuran
3.1: PCC / CH2Cl2 / 8 h / 25 °C
View Scheme
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
