三-o-乙酰基-5-脱氧-d-呋喃核糖合成路线 （共 24 条）
反应条件
1: 65 percent / CF3SO2OSiMe3, hexamethyldisilazane / CH2Cl2 / 20 h / Ambient temperature 2: 97 percent / CH3ONa / methanol / Ambient temperature View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: 5-fluoro-cytosine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane in toluene T=110°C; 0.5 h; 2: 1,2,3-Tri-O-acetyl-5-deoxy-D-ribofuranose With tin(IV) chloride in dichloromethane T=0 - 30°C; 3: With water; sodium hydrogencarbonate in dichloromethane 2 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KADABOINA, Rajasekhar; NARIYAM, Sekhar, Munaswamy; MURKI, Veerender; VINJAMURI, Raghupati, Rama; BENDA, Srinivas; KOMATI, Shravan, Kumar; GUNDA, Nageshwar
Patent: WO2010/65586 A2, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
tin(IV) chloride in dichloromethane T=0°C; 2 h;
参考文献
CRYSTAL BIOPHARMACEUTICAL LLC; CHEN, Yu; CHEN, Yi
Patent: WO2010/85377 A2, 2010 ;
Location in patent: Page/Page column 54 ;
WO 2010/085377 A2
反应条件
1.1: (NH4)2SO4; HMDS / m-xylene / Heating
1.2: 51 percent / TMSOTf / 1,2-dichloro-ethane / 18 h / Heating
2.1: H2; Et3N / 10percent Pd/C / dioxane / 4 h / 20 °C / 1292.9 Torr
3.1: NH3 / methanol / 20 °C
3.2: NaOAc / dimethylformamide / 1.5 h / 130 °C
View Scheme
参考文献
Wang, Guangyi; Tam, Robert C.; Gunic, Esmir; Du, Jinfa; Bard, Josie; Pai, Bharati
Journal of Medicinal Chemistry, 2000 , vol. 43, # 13 p. 2566 - 2574
