三-o-乙酰基-5-脱氧-d-呋喃核糖合成路线 （共 24 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in acetonitrile T=20°C; 14 h;
参考文献
Bookser, Brett C.; Ugarkar, Bheemarao G.; Matelich, Michael C.; Lemus, Robert H.; Allan, Matthew; Tsuchiya, Megumi; Nakane, Masami; Nagahisa, Atsushi; Wiesner, James B.; Erion, Mark D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7808 - 7820
反应条件
1: pyridine / CHCl3 / 0.5 h / 1.) 5 deg C, 1 h; 2.) up to RT, 20 h 2: 72 percent / NaI / butan-2-one / 18 h / Heating 3: 90 percent / H2, Et3N / 5percent Pd/C / methanol / 5 h / 22 °C / 760 Torr 4: 0.4N HCl / 1.) 95 deg C, 90 min; 2.) RT, 30 min 5: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: 85 percent / Ph3P, Br2 / CH2Cl2 / 1.) 5-8 deg C, 60 min; 2.) reflux, 4 h; 3.) 20-24 deg C, 14 h 2: 90 percent / KOH, H2 / 5percent Pd/C / methanol / 15 h / Ambient temperature 3: 1N HCl / H2O / 2 h / 110 °C 4: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: 72 percent / NaI / butan-2-one / 18 h / Heating 2: 90 percent / H2, Et3N / 5percent Pd/C / methanol / 5 h / 22 °C / 760 Torr 3: 0.4N HCl / 1.) 95 deg C, 90 min; 2.) RT, 30 min 4: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: HClO4 2: 85 percent / Ph3P, Br2 / CH2Cl2 / 1.) 5-8 deg C, 60 min; 2.) reflux, 4 h; 3.) 20-24 deg C, 14 h 3: 90 percent / KOH, H2 / 5percent Pd/C / methanol / 15 h / Ambient temperature 4: 1N HCl / H2O / 2 h / 110 °C 5: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: 90 percent / H2, Et3N / 5percent Pd/C / methanol / 5 h / 22 °C / 760 Torr 2: 0.4N HCl / 1.) 95 deg C, 90 min; 2.) RT, 30 min 3: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: 90 percent / KOH, H2 / 5percent Pd/C / methanol / 15 h / Ambient temperature 2: 1N HCl / H2O / 2 h / 110 °C 3: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: 74 percent / Et3N, H2 / 5percent Pd/C / methanol / 16 h / Ambient temperature 2: Ac2O/DMSO / 20 h / Ambient temperature 3: NaBH4 / ethanol; H2O / Ambient temperature 4: 0.4N HCl / 1.) 95 deg C, 90 min; 2.) RT, 30 min 5: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
反应条件
1: aq. H2SO4 2: 83 percent / 4-N,N-(dimethylamino)pyridine; Et3N / acetonitrile / 14 h / 20 °C View Scheme
参考文献
Bookser, Brett C.; Ugarkar, Bheemarao G.; Matelich, Michael C.; Lemus, Robert H.; Allan, Matthew; Tsuchiya, Megumi; Nakane, Masami; Nagahisa, Atsushi; Wiesner, James B.; Erion, Mark D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7808 - 7820
反应条件
1: NaBH4 / ethanol; H2O / Ambient temperature 2: 0.4N HCl / 1.) 95 deg C, 90 min; 2.) RT, 30 min 3: pyridine / 20 h / 20 °C View Scheme
参考文献
Kiss; D'Souza; Van Koeveringe; Arnold
Helvetica Chimica Acta, 1982 , vol. 65, # 5 p. 1522 - 1537
